Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases

Authors:	Romain Guilhaumou Nicolas Simon Sylvie Quaranta Arnauld Verschuur Bruno Lacarelle Nicolas Andre Caroline Solas

Affiliation:	1.Inserm U911, Faculté de Pharmacie,Marseille Cedex 5,France;2.Laboratoire de Pharmacocinétique et Toxicologie,H?pital de la Timone,Marseille Cedex 5,France;3.Laboratoire de Pharmacologie Médicale et Clinique,H?pital de la Timone,Marseille Cedex 5,France;4.Service d’Oncologie Pédiatrique, H?pital de la Timone,Marseille Cedex 5,France

Abstract:	Purpose The interindividual variability of vincristine pharmacokinetics is quite large, but the origins of this variability are not properly understood. The aim of this study was to develop a population pharmacokinetic model of vincristine in a paediatric population treated for solid tumour disease and evaluate the impact of different ABCB1, CYP3A4 and CYP3A5 polymorphisms on the different pharmacokinetic parameters.

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