Erythromycin-Induced Immune Hemolytic Anemia |
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Authors: | Sandra J Nance MS MTSBB Stephan Ladisch Timothy L Williamson and George Garratty |
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Institution: | American Red Cross Blood Services, Los Angeles-Orange Counties Region, Calif. |
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Abstract: | A 3-year-old female receiving Pediazole (erythromycin ethylsuccinate and sulfisoxazole) for tonsillitis and otitis media developed severe hemolytic anemia. No serum drug-dependent antibodies could be demonstrated with an in vitro 'immune-complex' method using Pediazole, pure erythromycin ethylsuccinate or pure sulfisoxazole. However, a method using red cells coated with erythromycin base showed in vitro lysis of the erythromycin-coated red cells. This is only the second case of immune hemolytic anemia associated with erythromycin and the first where in vitro drug-dependent hemolysis was demonstrable. |
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