Flax and Pumpkin seeds mixture ameliorates diabetic nephropathy in rats |
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| Authors: | Mohamed Makni Mediha Sefi Hamadi Fetoui El Mouldi Garoui Nabil K Gargouri Tahia Boudawara Najiba Zeghal |
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| Institution: | 1. Animal Physiology Laboratory, Faculty of Sciences, BP 1171, 3000 Sfax, Tunisia;2. Food Processing Department, ISET, BP 377, 9100 Sidi Bouzid, Tunisia;3. Histopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, Tunisia;1. Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Zemun, Serbia;2. Faculty of Technology, University of Novi Sad, Bul. Cara Lazara 1, 21000 Novi Sad, Serbia;3. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, 11001 Belgrade, Serbia;4. Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia;5. Military Medical Academy, Institute of Hygiene, Crnotravska 17, 11000 Belgrade, Serbia;1. Department of Fruit, Vegetable and Cereals Technology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland;2. Department of Food Storage and Technology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland;3. Department of Horticulture, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland;1. State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, PR China;2. State Engineering Laboratory of Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin 150040, PR China;3. Biotechnology Research Center, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, PR China;4. School of Pharmaceutical, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;1. Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia;2. Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria;3. Unit of Integrative Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia;2. Department of Clinical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt;3. Department of Biochemistry (HFK, SHF), Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia;4. Department of Pharmacology & Clinical Pharmacy (SME), Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia;1. Food Conservation and Valorization Laboratory, High Institute of Food Industries, 58 Alain Savary Street, El Khadra City, Tunis, 1003, Tunisia;2. Faculty of Science of Bizerte, Zarzouna, 7021, Bizerte, Tunisia;3. Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria Technopole, BP. 901, Hammam-Lif, 2050, Tunisia |
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| Abstract: | This study investigated the hypoglycemic and antioxidant effects of Flax and Pumpkin seeds mixture on the kidney of alloxan-induced diabetic rats. Animals were allocated into three groups of six rats each: a control group (CD), a diabetic group (DD) and diabetic rats fed with Flax and Pumpkin seeds mixture (DMS) group. The DD rats showed a significant increase of glycemia and lipid parameters such as total lipid, total cholesterol and triglycerides levels compared to those of the control group (CD). In addition, plasma and kidney malonaldialdehyde levels (MDA) were significantly increased compared to (CD) group. Antioxidant enzyme activities such as catalase (CAT), superoxide dismutase (SOD) and non-enzymatic levels of reduced glutathione (GSH) significantly decreased in the plasma and kidney of diabetic rats compared to those of controls. Diet supplemented with Flax and Pumpkin seeds mixture ameliorated the antioxidant enzymes activities observed in diabetic rats and significantly decreased MDA levels. Kidney histological sections, showed glomerular hypertrophy and tubular dilatation. In DMS rats, these histopathological changes were less prominent. Our results suggest that Flax and Pumpkin seeds mixture supplemented in diet of diabetic rats may be helpful to prevent diabetes and its complications. |
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