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| 家兔体内呋喃苯胺酸的药动学和药效学结合模型 | |
| 引用本文： | 柳晓泉 黄圣凯. 家兔体内呋喃苯胺酸的药动学和药效学结合模型[J]. 中国药理学与毒理学杂志, 1991, 5(2): 136-138 |
| 作者姓名： | 柳晓泉 黄圣凯 |
| 作者单位： | 中国药科大学药理教研室，中国药科大学药理教研室，中国药科大学药理教研室，中国药科大学药理教研室 南京 210009，南京 210009，南京 210009，南京 210009 |
| 基金项目： | 江苏省科学技术委员会资助 |
| 摘 要： | 用药动学-药效学结合模型对呋喃苯胺酸在家兔体内的处置和效应动力学作定量分析。呋喃苯胺酸的k_(eo),S,E_(max),EC_(50)分别为0.131±0.029min~(-1),2.21±0.61,6.5±0.6ml/min,3.49±0.77μg/ml。结果表明血浆与作用部位属于不同的房室,两者之间存在着一个平衡过程。 |
| 关 键 词： | 呋喃苯胺酸 药动学 药效学 效应室 药动学-药效学结合模型 |
Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits |
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| LIU Xiao-Quan,HUANG Sheng-Kai,LU Hong,YANG Jin-Yu Dept Pharmacology,China Pharmaceutical University,Nanjing. Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits[J]. Chinese Journal of Pharmacology and Toxicology, 1991, 5(2): 136-138 | |
| Authors: | LIU Xiao-Quan HUANG Sheng-Kai LU Hong YANG Jin-Yu Dept Pharmacology China Pharmaceutical University Nanjing |
| Affiliation: | LIU Xiao-Quan,HUANG Sheng-Kai,LU Hong,YANG Jin-Yu Dept Pharmacology,China Pharmaceutical University,Nanjing 210009 |
| Abstract: | The pharmacokinetic and pharma codynamic profiles of furosemide were analyzed by the combined pharmacokinetic and pharmacodynamic model in rabbits. The pharmacodynamic parameters keo(the elimination rate constant of the effect compartment), S(Hill coefficient), EC50(the drug concentration at helf maximum effect), Emax(the maximum drug effect) for furosemide ((x|-)±SD) were 0.131±0.029 min-', 2.2±0.6, 3.5±μ0.8 μg/ml, and 6.5±0.6 ml/min, respectively. Following an iv dose offurosemide, its maximal diuretic effect occurred after the peak plasma concentration. This indicates that the plasma and effect site belong to different compartments and the equilibrium between the plasma and effect site does not reach instantaneously. |
| Keywords: | furosemide pharmacokinetics pharmacodynamics effect compartment combined pharmacokinetic and pharmacodynamic model |
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