3种广枣提取物对哇巴因诱发豚鼠心律失常作用的比较 |
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引用本文: | 周丽波,杨玉梅,应康,徐继辉,覃建民,张长在,白音夫,宋一亭.3种广枣提取物对哇巴因诱发豚鼠心律失常作用的比较[J].中国民族医药杂志,2008,14(1):34-36. |
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作者姓名: | 周丽波 杨玉梅 应康 徐继辉 覃建民 张长在 白音夫 宋一亭 |
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作者单位: | 1. 内蒙古自治区医院,呼和浩特,010017 2. 内蒙古包头医学院心血管研究室,包头,014010 3. 内蒙古自治区中蒙医研究所,呼和浩特,010020 |
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摘 要: | 目的:观察广枣中3种提取物对哇巴因所致心律失常的影响,为找到一种抗心律失常作用较强的主要化学单体或简单复合物打下基础。方法:采用Langendorg灌流法,观察药物对哇巴因所致离体豚鼠心脏心律失常的影响;给豚鼠恒速iv哇巴因致心律失常,观察药物的抗心律失常作用。结果:与空白对照组比,样品1、样品2使豚鼠离体心脏出现室颤时所需哇巴因的量增加,并呈明显的剂量依赖性;样品3使豚鼠离体心脏出现室颤所需哇巴因的量变化不大。样品1、样品2使哇巴因引起豚鼠早搏、室颤、室额、心脏停搏时的剂量明显增加,并呈明显的剂量依赖性:样品3使早搏、室速、心脏停搏时的剂量变化不明显,但可使室颤出现时的剂量明显降低。结论:样品1、样品2能对抗哇巴因所导致的心律失常的发生:而样品3不仅没有对抗作用,还有可能促进心律失常的发生。
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关 键 词: | 广枣提取物 哇巴因 心律失常 |
文章编号: | 1006-6810(2008)01-0034-03 |
修稿时间: | 2007年2月9日 |
Comparing the action of the three extracts in Choerospondias Axillaries (Roxb.)Burtt et Hill on arrhythmias induced by ouabain |
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Institution: | Yang Yumei, Ying Kang, xu Jihui ,Qin Jianmin, Zhang Changzai, Song Yiting,Bai Yinfu ,Song Yiting (1. Departement of Cardiovascular Research, Baotou Medical college, Baotou 014010 ;2. Instiut of Inner Mengol Chinese - Mengol Medicine, Huhhot 010020) |
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Abstract: | Objective:To compare the actions of the three extracts in Choerospondias Axillaries (Roxb.)Burtt et Hill on arrhythmias induced by ouabain. Method:Langendorff perfuse was applied in the experiment, the antiarrhythmic action was to study by using ouabain on the guinea pig isolated heart;The antiarrhythmic action of the three extracts in Choerospondias Axillaries (Roxb.) Burtt et Hill was to study by using iv ouabain in guinea pig to induce arrhythmias. Result:compared with the NS group,Sample 1 and sample 2 both significantly prolonged the beginning time of VF ot isolated heart and increased the dosage of ouabain, Sample 3 didn' t change on the beginning time of VF of isolated heart;Sample 1 and sample 2 both greatly prolonged the beginning time of VE,VT, VF, HA;Sample 3 reduced the beginning time of VF. The actions of the three samples were in a concentration- dependent way. Conclusion: Sample 1 and Sample 2 both resisted the occurrence of arrhythmias induced by ouabain, Sample 3 and Sample 2 both resisted the occurrence of arrhythmias induced by ouabain, Sample 3 markedly promoted the occurrence of arrhythmias induced by ouabain. |
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Keywords: | extracts of Choerospondias Axillaries (Roxb ) Burtt et Hill ouabain arrhythmias |
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