| 慢性疲劳应激对大鼠伏隔核一氧化氮合酶表达的影响 |
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| 引用本文： | 刘鸿宇,杨桂姣,崔建梅,宋晓霞.慢性疲劳应激对大鼠伏隔核一氧化氮合酶表达的影响[J].解剖学杂志,2008,31(4). |
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| 作者姓名： | 刘鸿宇 杨桂姣 崔建梅 宋晓霞 |
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| 作者单位： | 1. 中北大学生理学实验室,太原,030051
2. 山西医科大学人体解剖学教研室,太原,030001 |
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| 基金项目： | 中北大学校科研和教改项目 |
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| 摘 要： | 目的:探讨长时间游泳引起的疲劳应激对大鼠伏隔核(NAc)中神经元型一氧化氮合酶(nNOS)表达的影响.方法:采用成年雄性大鼠连续4周每天强迫游泳至力竭,用免疫组织化学方法结合图像处理测定伏隔核中nNOS的表达.结果:长时间强迫游泳应激可使大鼠伏隔核巾nNOS免疫细胞化学反应阳性神经元的数量(106.7%)、面积(150.2%)和灰度值(11.3%)显著增加.结论:nNOS参与疲劳应激的形成,一氧化氮在伏隔核对应激调节中起重要作用.
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| 关 键 词： | 疲劳应激 神经元型一氧化氮合酶 伏隔核 |
Effects of chronic fatigue on the expression of nitric oxide synthase in rat nucleus accumbens |
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| Liu Hongyu,Yang Guijiao,Cui Jianmei,Song Xiaoxia.Effects of chronic fatigue on the expression of nitric oxide synthase in rat nucleus accumbens[J].Chinese Journal of Anatomy,2008,31(4). |
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| Authors: | Liu Hongyu Yang Guijiao Cui Jianmei Song Xiaoxia |
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| Abstract: | Objective: To assess the effects of chronic fatigue induced by swimming on the expression of neuronal nitric oxide synthase(nNOS) in the rat nucleus accumbens.Methods: Adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks.Immunohistochemistry combined with the image manipulation was used for the measurement of nNOS positive neurons.Results: A long-time exposure to chronic forced swimming significantly increased the number(106.7%),distributed area(150.2%) and gray degree(11.3%) of nNOS immunoreactive positive neurons in the nucleus accumbens.Conclusion: nNOS might be involved in the formation of fatigue stress,and that nitric oxide(NO) might play an important role in the regulation of stress in the nucleus accumbens. |
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| Keywords: | fatigue stress neuronal nitric oxide synthase nucleus accumbens |
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