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Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha
Authors:Phurpa Wangchuk  John B. Bremner  Samten  Roonglawan Rattanajak  Sumalee Kamchonwongpaisan
Affiliation:1. Pharmaceutical and Research Unit, Institute of Traditional Medicine Services, Department of Medical Services, Ministry of Health, Thimphu, Bhutan;2. School of Chemistry, University of Wollongong, NSW 2522, Australia;3. BIOTEC Central Research Unit, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand
Abstract:
The alkaloidal components of the Bhutanese medicinal plant Corydalis calliantha Long, which is used for the treatment of malaria, have been assessed. Four known alkaloids, protopine (1), scoulerine (2), cheilanthifoline (3) and stylopine (4) are reported from this plant for the first time. The protopine alkaloid, protopine, and the tetrahydroprotoberine alkaloid, cheilanthifoline, showed promising in vitro antiplasmodial activities against Plasmodium falciparum, both wild type (TM4) and multidrug resistant (K1) strains with IC50 values in the range of 2.78–4.29 µm . Such activity had not been demonstrated previously for cheilanthifoline. The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified cheilanthifoline as a potential new antimalarial drug lead. Copyright © 2009 John Wiley & Sons, Ltd.
Keywords:antiplasmodial  alkaloids  Corydalis calliantha  medicinal plants  Bhutanese traditional medicine
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