“Atypical steroid response” in a pulmonary inflammatory myofibroblastic tumor |
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| Authors: | Oliviero Sacco MD Claudio Gambini MD Chiara Gardella MD Paolo Tomà MD Umberto G. Rossi MD Vincenzo Jasonni MD Andrew Bush MD Giovanni A. Rossi MD |
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| Affiliation: | 1. Pediatric Pulmonary and Allergology Unit, Giannina Gaslini Research Institute, Genova, Italy;2. Pathology Unit, Giannina Gaslini Research Institute, Genova, Italy;3. Radiology Unit, Giannina Gaslini Research Institute, Genova, Italy;4. Department of Diagnostic and Interventional Radiology, San Martino University Hospital, Genova, Italy;5. Pediatric Surgery Unit, Giannina Gaslini Research Institute, Genova, Italy;6. Department of Paediatric Respirology, Royal Brompton Hospital, London, UK |
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| Abstract: | ![]()
A 6‐year‐old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well‐circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor. Pediatr Pulmonol. 2010; 45:721–726. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | inflammatory myofibroblastic tumor plasma cell granuloma atelectasis mediastinal mass |
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