Langerhans cell histiocytosis with digestive tract involvement |
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| Authors: | Satya P. Yadav DCH DNB Gaurav Kharya DCH DNB Neelam Mohan DNB Anupam Sehgal DNB Sunil Bhat MD Sandeep Jain MD Gauri Kapoor MD PhD Anupam Sachdeva DCH MD |
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| Affiliation: | 1. Pediatric Haematology and Oncology and Bone Marrow Transplantation Unit, Department of Pediatrics, Center for Child Health, Sir Ganga Ram Hospital, Delhi, India;2. Pediatric Gastroenterology and Hepatology Unit, Department of Pediatrics, Center for Child Health, Sir Ganga Ram Hospital, Delhi, India;3. Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India |
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| Abstract: | ![]()
Gastrointestinal tract (GIT) involvement in Langerhans cell histiocytosis (LCH) is not commonly described. We present two children presenting with GIT involvement with LCH, one successfully treated on standard protocol and other being treated on a protocol for relapsed disease. A review of literature showed almost 95% children were less than 2 years of age and 62% were females. Vomiting, abdominal pain, constipation, intractable diarrhea, malabsorption, bloody stools, protein‐losing enteropathy, and even intestinal perforation are some of the reported symptoms. More than 50% patients died within 18 months from diagnosis. Pediatr Blood Cancer. 2010;55:748–753. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | gastrointestinal Langerhans cell histiocytosis protein losing enteropathy |
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