Antioxidant activities of coumarins from Korean medicinal plants and their structure–activity relationships |
| |
| Authors: | Phuong Thien Thuong Tran Manh Hung Tran Minh Ngoc Do Thi Ha Byung Sun Min Seung Jun Kwack Tae Suk Kang Jae Sue Choi KiHwan Bae |
| |
| Affiliation: | 1. College of Pharmacy, Chungnam National University, Daejeon 305‐764, Korea;2. National Institute of Medical Materials 3B_ Quang Trung, Hanoi, Vietnam;3. Current address: National Institute of Medical Materials 3B_ Quang Trung, Hanoi, Vietnam;4. College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712‐702, Korea;5. Department of Toxicological Research, National Institute of Toxicological Research, Seoul 122‐704, Korea;6. Faculty of Food Science and Biotechnology, Pukyoung National University, Busan 608‐737, Korea |
| |
| Abstract: | ![]()
The aim of this work was to study the structure–activity relationships of the antioxidant activity of natural coumarins isolated from four Korean medicinal plants (1–17) and four purchased coumarins (18–21). The free radical scavenging and lipid peroxidation assays revealed that five phenolic coumarins, scopoletin (1), aesculetin (2), fraxetin (3), umbelliferone (18) and daphnetin (19), possessed considerable antioxidant activities. The coumarins having a catechol group, 2, 3 and 19, showed significant free radical scavenging activity and inhibitory effects on lipid peroxidation, indicating that the catechol group significantly contributed to the antioxidant activities of coumarins. In contrast, the sugar moiety markedly reduced the activities of coumarin glycosides. The results also demonstrate that the α‐pyrone ring of coumarins significantly enhanced the capacity of inhibiting oxidative reactions of coumarins. Copyright © 2009 John Wiley & Sons, Ltd. |
| |
| Keywords: | coumarin antioxidant activity structure‐activity relationship α ‐pyrone ring |
|
|
