隔药饼灸对子宫内膜异位症大鼠新血管生成的影响

目的:探讨隔药饼灸对子宫内膜异位症大鼠血管生成的影响。方法:将大鼠分为空白对照组、隔药饼灸组、西药组以及模型对照组,分别进行相应处理,14 d后处死,检测实验各组标本的Ang-1和Ang-2的表达。结果:与正常组比较,模型组、艾灸组和达那唑组大鼠的Ang-1表达均相对升高(P0.05),与模型组比较,艾灸组和达那唑组大鼠Ang-1表达有所降低,但差异无统计学意义(P0.05),与正常组比较,模型组、艾灸组和达那唑组大鼠的Ang-2表达显著升高(P0.05),与模型组比较,艾灸组和达那唑组大鼠Ang-2表达显著降低(P0.05)。结论:隔药饼灸可能通过促进降低Ang-2的表达,抑制血管异常增生而达到治疗子宫内膜异位症目的。

Effect of Aconite-cake-partitioned Moxibustion on Angiogenesis in Rats with Endometriosis

To study the effect of aconite-cake-partitioned moxibustion on angiogenesis in rats with endometriosis. Methods:The rats were randomly divided into control group, model group, moxibustion Group and Dalazol group. Rats in the four groups received treatment for 14 days and samples were made to detect the expression of ang-1 and ang-2 by western blotting assay. Results:Compared with the control group, the ang-1 expression in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05). Compared with the model group, the ang-1 expression in the moxibustion group and Dalazol group were slightly decreased, but without significantly difference (P>0.05). Meanwhile, the expression of ang-2 in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05), compared with the control group. The expression of ang-2 in the moxibustion group and Dalazol group were significantly decreased, compared with model group (P<0.05). Conclusion:Aconite-cake-partitioned moxibustion on CV4 can treat endometriosis by decreasing the expression of ang-2 and inhibiting the angiogenesis.