| 铜绿假单胞菌生物膜形成机制及中药对其调控作用研究进展 |
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| 引用本文： | 何莎莎,赵京霞,徐霄龙,郭玉红,刘清泉.铜绿假单胞菌生物膜形成机制及中药对其调控作用研究进展[J].世界中医药,2016(10). |
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| 作者姓名： | 何莎莎 赵京霞 徐霄龙 郭玉红 刘清泉 |
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| 作者单位： | 1 首都医科大学附属北京中医医院，北京，100010； 2 中医感染性疾病基础研究北京市重点实验室，北京，100010； 3 北京市中医研究所，北京，100010； 4 北京中医医院顺义医院，北京，101300 |
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| 基金项目： | 北京市医院管理局重点医学专业发展计划专项（编号：ZYLX201611）；国家科技重大专项课题(编号：2013ZX09102026） |
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| 摘 要： | 铜绿假单胞菌是一种能引起机体急性或慢性感染的条件致病菌,极易形成生物膜是其产生耐药的一个重要因素。近年来研究表明,中药对铜绿假单胞菌生物膜形成具有明显的抑制作用。作者就铜绿假单胞菌生物膜形成周期、生物膜形成的主要调控信号系统以及中药对生物膜形成的影响进行综述。
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| 关 键 词： | 铜绿假单胞菌 生物膜 中药 |
| 收稿时间： | 2016/9/12 0:00:00 |
Research Progress of Pseudomonas Aeruginosa Biological Film Formation Mechanism and Its Chinese Material Medica Regulations |
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| He Shash,Zhao Jingxi,Xu Xiaolong,Guo Yuhong,Liu Qingquan.Research Progress of Pseudomonas Aeruginosa Biological Film Formation Mechanism and Its Chinese Material Medica Regulations[J].World Chinese Medicine,2016(10). |
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| Authors: | He Shash Zhao Jingxi Xu Xiaolong Guo Yuhong Liu Qingquan |
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| Institution: | 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing 100010, China; 2 Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China; 3 Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing 100010, China; 4 Beijing Hospital of Traditional Chinese Medicine Shunyi Branch, Beijing 101300, China |
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| Abstract: | Pseudomonas aeruginosa is an opportunistic pathogenic bacterium that causes acute or chronic infection, one of its drug resistance factor is to form biological film easily. According to recent studies, Chinese material medica has significant inhibitory effect on pseudomonas aeruginosa biological film formation. The author reviewed the biological film formation cycle of pseudomonas aeruginosa, the major regulatory signal system for biofilm formation and the impact of Chinese material medica on it. |
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| Keywords: | Pseudomonas aeruginosa Biological film Chinese material medica |
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