| 清肝化瘀方质量标准研究 |
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| 引用本文： | 吴桐,张巧丽,姚树坤.清肝化瘀方质量标准研究[J].世界中医药,2017(10). |
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| 作者姓名： | 吴桐 张巧丽 姚树坤 |
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| 作者单位： | 1 首都医科大学附属北京地坛医院,北京,100015； 2 北京市和平里医院,北京,100013; 3 中日友好医院,北京,100029 |
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| 基金项目： | 国家重大新药创制专项课题(2012ZX09103201-021)——清肝化瘀胶囊治疗原发性肝癌的候选药物研究 |
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| 摘 要： | 目的:建立清肝化瘀颗粒的质量控制方法。方法:采用薄层色谱法,鉴别黄芩、苦参、半枝莲、莪术等组成药物;采用高效液相色谱法测定方中君药黄芩、苦参的主要成分黄芩苷及苦参碱的含量。结果:确立了颗粒中黄芩、苦参、莪术、半枝莲的薄层色谱鉴别方法。在选定的高效液相色谱条件下,建立了本颗粒中黄芩苷、苦参碱的测定方法,其方法学均符合药典要求。结论:本实验建立的鉴别和含量测定方法简便、准确、重复性好,适用于本颗粒质量的控制。
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| 关 键 词： | 清肝化瘀颗粒 薄层鉴别 黄芩苷 苦参碱 质量标准 |
| 收稿时间： | 2016/7/12 0:00:00 |
Study on Quality Standard of Qinggan Huayu Granule |
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| Wu Tong,Zhang Qiaoli,Yao Shukun.Study on Quality Standard of Qinggan Huayu Granule[J].World Chinese Medicine,2017(10). |
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| Authors: | Wu Tong Zhang Qiaoli Yao Shukun |
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| Institution: | 1 Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100015, China; 2 Beijing Hepingli Hospital, Beijing 100013, China; 3 China-Japan Friendship Hospital, Beijing 100029, China |
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| Abstract: | To establish a quality-control method for Qinggan Huayu Granule. Methods:TLC (Thin Layer Chromatography) was adopted to identify Radix Scutellariae, Radix Sophorae Flavescentis, Scutellaria barbata, zedoary etc. The main content of baicalin and matrine in the principal drug Radix Scutellariae, Radix Sophorae Flavescentis are determined by HPLC (high performance liquid chromatography) method. Results:Identification method of the TLC about Radix Scutellariae, Radix Sophorae Flavescentis, Scutellaria barbata, zedoary etc in granules was established. Under the selected conditions of HPLC, an identification method for baicalin and matrine in granules was established and the methodology complies with the requirements of Chinese Pharmacopeia. Conclusion:The identification and quantitative determination method is simple, accurate and reproducible, which can be applied to the quality control of Qinggan Huayu Granule. |
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