血浆GLP-1水平对糖尿病胃轻瘫病人固体胃排空影响

目的 探讨糖尿病胃轻瘫(DGP)病人血浆胰高糖素样肽=1(GLP-1)水平对固体胃排空的影响.方法 应用放射性核素法对55例2型糖尿病病人及15例正常人(NC组)进行固体胃半排空时间(T1/2)测定.根据T1/2结果将糖尿病病人分为胃排空时间正常的DM组和胃排空延迟的DGP组.采用酶联免疫吸附法检测各组空腹及餐后30、...

EFFECT OF GLP-1 ON SOLID GASTRIC EMPTYING IN PATIENTS WITH DIABETES GASTROPARESIS

Objective To investigate the influence of plasma level of glucagon-like peptide-1(GLP-1) on solid gastric emptying in patients with diabetes gastroparesis(DGP). Methods Using radioactive nuclide technique,solid gastric half-emptying time(T1/2) in 55 patients with type 2 diabetes and 15 health adults were measured.According to the T1/2 results,the patients were divided into normal gastric emptying(DE) group and DGP group.The plasma levels of GLP-1 in all subjects were measured by enzyme-linked immunosorbent assay at fasting and 30 min and 120 min after meals. Results Compared with the normal control,the fasting GLP-1 level and that 30 min after meals in DM group declined(F=37.202,108.304;q=2.933,3.654;P<0.05);but that 120 min after meals and T1/2 showed no statistical differences between the two groups;Compared with normal control and DM group,GLP-1 levels at fasting and 30 min after meals in DGP group increased obviously(q=4.336-14.606,P<0.05),GLP-1 levels at 120 min after meals had no statistical differences,T1/2 significantly delayed(F=61.562;q=7.994,10.585;P<0.05).In DM group,fasting GLP-1 and that 30 min after meals were not correlated with T1/2;In DGP group,the GLP-1 levels at fasting and 30 min after meals were positively correlated with T1/2(r=0.482,0.560;P<0.05).Conclusion Delayed gastric emptying in DGP patients is likely to be associated with elevation of fasting plasma levels of GLP-1 and that 30 min after meals.