| 月桂酰吲达帕胺的电离常数及分配系数的测定 |
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| 引用本文： | 索绪斌,邓英杰,郝爱军,张晓燕.月桂酰吲达帕胺的电离常数及分配系数的测定[J].沈阳药科大学学报,2005,22(5):335-337. |
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| 作者姓名： | 索绪斌 邓英杰 郝爱军 张晓燕 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的测定月桂酰吲达帕胺的电离常数(pKa)及分配系数。方法采用酸碱滴定法测定各不同体积比的丙酮-水溶液中药物半中和点时的pH值作为药物在该体积比的丙酮-水溶液中的pKa值,再外推至纯水中药物浓度无限稀释时的pKa值;采用HPLC配合摇瓶法测定药物的分配系数。结果月桂酰吲达帕胺的pKa为3.87,lgP值为3.190。结论月桂酰吲达帕胺为弱酸性亲脂性药物。
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| 关 键 词： | 月桂酰吲达帕胺 电离常数 分配系数 |
| 文章编号： | 1006-2858(2005)05-0335-03 |
| 收稿时间： | 2004-12-06 |
| 修稿时间： | 2004年12月6日 |
Determination of the ionization constant and partition coefficient of lauroyl indapamide |
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| SUO Xu-bin,DENG Ying-jie,HAO Ai-jun,ZHANG Xiao-yan.Determination of the ionization constant and partition coefficient of lauroyl indapamide[J].Journal of Shenyang Pharmaceutical University,2005,22(5):335-337. |
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| Authors: | SUO Xu-bin DENG Ying-jie HAO Ai-jun ZHANG Xiao-yan |
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| Abstract: | Objective To determine the ionization constant and partition coefficient of lauroyl indapamide.Methods The ionization constant was determined with acid-basie titration in acetone/water solutions with different ratios,the pH at half neutralization point was regarded as pKa,the value to infinite diluted in pure water was explored and the lgP was determined with bottle-shaking method by HPLC.Results The pKa and lgP of lauroyl indapamide were 3.87 and 3.190 respectively.Conclusions Lauroyl indapamide is a weak acid with lipophilic property. |
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| Keywords: | lauroyl indapamide ionization constant partition coefficient |
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