新生儿窒息复苏后早期凝血功能的变化及临床意义

目的探讨新生儿窒息复苏后早期凝血功能的变化及其临床意义。方法检测58例窒息复苏后的新生儿血浆D-二聚体(DD)、蛋白C(PC)水平以及凝血酶原时间(PT)、凝血酶时间(TT)和部分活化凝血活酶时间(APTT),并与20例正常新生儿比较。结果重度窒息组血浆DD值增高,PC值降低,与正常对照组或轻度窒息组比较差异具有显著性意义(P<0.01)。轻度窒息组血浆DD值亦增高,与正常对照组比较差异具有显著性意义(P<0.01),而PC值与正常对照组比较差异无显著性意义(P>0.05)。轻度窒息组和重度窒息组血浆PT、TT、及APTT均较对照组延长,比较差异具显著性意义(P<0.05和P<0.01);重度窒息组PT、TT及APTT与轻度窒息组比较,差异亦具显著性意义(P<0.01)。结论新生儿窒息复苏后早期多数存在凝血功能紊乱,主要表现高凝状态,且凝血功能紊乱程度与窒息程度相关。对窒息新生儿复苏后早期进行凝血功能监测具有重要的临床意义。

Early Stage Coagulation Functional Change and Clinical Significance about Newborn Baby Recovery from Stifle

Objective To evaluate early coagulation functional change and the clinical significanceof newborn baby recovery from stifle.Methods A total of 58 newborn baby recovery form stifle werechecked DD.PC.PT.TT and APTT in blood plasma And contrast with 20 cases normal newborn baby. ResultsThe blood plasma DD increase and PC decrease in the group of heavy stifle .There is a significancedifference contrast to normal group or light stifle group.(p<0.01).The blood plasma DD in light stiflegroup also increase,there is a significant difference between normal group(p<0.01).And PC isn't asignificant difference between with normal group. The blood plasma PT.TT and APTT in light and heavystifle group longer than contrast group. There is a significant difference between them(p<0.05 and p<0.01)The PT.TT and APTT is a significant difference between light with heavy (p<0.01). Conclusion Theymajority will be coagulation function disorder in newborn baby recovery early stage from stifle. Theymost manifest hight coagulation state and the coagulation functional disorder. There will be veryimportant clinical significance to check coagulation function in newborn baby recovery early stage fromstifle.