加味升降散治疗原发性膜性肾病临床研究

目的:研究加味升降散对原发性膜性肾病(IMN)的临床疗效。方法:将60例确诊为原发性膜性肾病的患者随机分为治疗组和对照组,每组30例,对照组患者单纯给予西医治疗,治疗组患者在对照组基础上加用加味升降散,分别于治疗前、治疗后1个月、2个月对患者的临床症状积分、24 h尿蛋白定量、血清总蛋白、白蛋白、总胆固醇、甘油三酯、血尿素氮、血肌酐、血尿酸、血常规、谷丙转氨酶、谷草转氨酶进行检测分析。结果:与治疗前相比,治疗后1个月,治疗组浮肿、倦怠乏力积分较治疗前有所下降(P0.05);治疗后2个月,两组浮肿、倦怠乏力、纳呆口腻、腹胀身重积分较治疗前下降(P0.05),其中浮肿、倦怠乏力积分较治疗前显著下降(P0.01),治疗组优于对照组(P0.05)。与治疗前相比,治疗后1个月两组24 h尿蛋白定量均有所下降(P0.05),治疗后2个月与治疗前相比,两组24 h尿蛋白定量下降显著(P0.01),治疗组优于对照组(P0.01);与治疗前相比,治疗后2个月两组血清总蛋白、白蛋白均有所上升(P0.05);与治疗前相比,治疗后2个月两组血清总胆固醇、甘油三酯均有所下降(P0.05),总胆固醇下降显著(P0.01);与治疗前相比,两组血常规、谷丙转氨酶、谷草转氨酶、血尿素氮、血肌酐、血尿酸未见明显变化。结论:加味升降散具有减轻IMN患者临床症状、降低尿蛋白、提高血浆蛋白水平、降低血脂的作用,且安全性可靠。

Clinical Study on Supplemented Shengjiang San in Treatment of Idiopathic Membranous Nephropathy

Objective:to study the curative effect of supplemented Shengjiang San in treatment of idiopathic membranous nephropathy (IMN). Methods:60 IMN cases were randomly divided into control group and treatment group ,the former trea‐ted with western medicine while the latter added with Supplemented Shengjiang San to western medicine. One month and two months before and after treatment ,respectively detect and analyze clinical symptoms integral ,24h urine protein ration ,serum total protein ,albumin ,total cholesterol ,triglyceride ,blood urea nitrogen ,serum creatinine ,blood uric acid ,blood routine , glutamate pyruvate transaminase ,and glutamic-oxalacetic transaminase. Results:one month after treatment ,oedema and fa‐tigue integral in treatment group decreased compared to pretreatment ( P<0.05);two months after treatment ,integrals of oe‐dema ,fatigue ,greasy sensation ,abdominal distension and heavy body in both groups all decreased ( P<0.05) ,among which , oedema and fatigue integrals decreased significantly ( P<0.01) ,treatment group superior to control group ( P<0.05). One month after treatment ,24 h urine protein ration of both groups decreased ( P<0.05);two months after treatment ,24 h urine protein ration of both groups decreased significantly ( P<0.01) ,treatment group superior to control group ( P<0.01);ser‐um total protein and albumin increased ( P <0.05) ,total cholesterol and triglyceride decreased ( P <0.05);and there were no significant changes in blood routine ,glutamate pyruvate transaminase ,glutamic-oxalacetic transaminase ,blood urea nitro‐gen ,serum creatinine and blood uric acid. Conclusion:Supplemented Shengjiang San can ,with reliability ,relieve the symp‐toms in IM N patients ,decrease urine protein ,increase blood protein level and decrease blood fat.