PCNA与BCL-2的表达在大肠癌预后评估中的意义

目的　研究PCNA与BCL - 2的表达在大肠癌预后评估中的意义。方法　用sABC免疫组化法分析 3年随访期间大肠癌患者肠标本的PCNA与BCL - 2的表达。结果　PCNA在正常大肠黏膜中不表达而在大肠癌中呈阳性表达 ,PCNA与肿瘤的复发、患者的死亡时间、肿瘤分期和淋巴道转移呈正相关 (P <0 .0 5 ) ,而与患者的年龄、性别和肿瘤部位呈负相关。BCL - 2仅与肿瘤分期高度相关 (P <0 .0 5 ) ,与复发时间、死亡时间、年龄、性别和肿瘤部位无关 (P >0 .0 5 )。结论　分析PCNA与BCL - 2的表达对大肠癌的临床治疗和预后评估具有重要意义

Prognostic evaluation of PCNA and BCL-2 expression in colorectal carcinoma

Objective:To investigate the prognostic evaluation of PCNA and BCL-2 expression in patients with colorectal carcinoma.Methods:Utilizing sABC Immunohistochemical methods, PCNA and BCL-2 expression of specimens from patients with colorectal carcinoma during a three-year follow-up were analyzed.Results: PCNA and BCL-2 expression was negative in normal colorectal mucosae but positive in colorectal carcinoma. PCNA demonstrated a positive correlation ( P <0.05) with the recurrence and death time of patient, tumor stage and lymphatic metastasis, but a negative correlation with patient's age, gender and tumor location. BCL-2 only shared a highly positive correlation ( P <0.05)with tumor stage and no obvious correlation ( P >0.05) with such factors as recurrence time, death time, age, gender and tumor location.Conclusions:PCNA and BCL-2 expression analysis is of important value in clinical treatment and prognostic evaluation of colorectal carcinoma.