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| 赤芍与白芍抗血小板凝集作用的UPLC-MS代谢组学初步研究 | |
| 引用本文： | 杨琪伟,杨莉,熊爱珍,王瑞,王峥涛. 赤芍与白芍抗血小板凝集作用的UPLC-MS代谢组学初步研究[J]. 中国中药杂志, 2011, 36(6): 698-701 |
| 作者姓名： | 杨琪伟 杨莉 熊爱珍 王瑞 王峥涛 |
| 作者单位： | 1. 上海中医药大学,中药学院,上海,201203 2. 上海中药标准化研究中心,上海,201203;上海中医药大学中药研究所中药标准化教育部重点实脸室,上海,201203 3. 上海中医药大学,中药学院,上海,201203;上海中药标准化研究中心,上海,201203 |
| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09308-003,2009ZX09502-021);上海市自然科学基金项目(08ZR1419100);中医药行业科研专项(200707009) |
| 摘 要： | 目的:利用代谢组学方法研究赤芍和白芍的抗血小板凝集功能及对大鼠内源性代谢物的影响.方法:赤芍和白芍各给药6d后,观察赤芍和白芍对大鼠血小板凝聚功能的影响,并采用超高效液相色谱-电喷雾质谱(UPLC-MS)技术分析大鼠血清代谢物指纹图谱,采用偏最小二乘判别分析法研究给药组与正常组之间的代谢物组差异,寻找可能的生物标识物.结果:连续给予赤芍和白芍提取物6d后,能显著降低大鼠血小板最大凝集率水平,且赤芍组与白芍组组间有明显差别(P<0.01).α-酮戊二酸、苹果酸、白细胞三烯A4、前列腺素E2、前列腺素F2.等内源性生物标识物对于表征赤芍、白芍的抗血小板凝聚作用具有重要的作用.结论:代谢组学研究可以深人探讨赤芍和白芍的抗血小板凝聚机制. |
| 关 键 词： | 代谢组学 UPLC-MS 赤芍 白芍 抗血小板凝集 |
| 收稿时间： | 2011-02-24 |
Metabolomics study of anti-platelet effect of Radix Paeoniae Rubra and Radix Paeoniae Alba by UPLC-MS |
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| YANG Qiwei,YANG Li,XIONG Aizhen,WANG Rui and WANG Zhengtao. Metabolomics study of anti-platelet effect of Radix Paeoniae Rubra and Radix Paeoniae Alba by UPLC-MS[J]. China Journal of Chinese Materia Medica, 2011, 36(6): 698-701 | |
| Authors: | YANG Qiwei YANG Li XIONG Aizhen WANG Rui WANG Zhengtao |
| Affiliation: | School of Pharmacy, Shanghai University of Traditional Chinese Medicines, Shanghai 201203, China;Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China;MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China;MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;School of Pharmacy, Shanghai University of Traditional Chinese Medicines, Shanghai 201203, China;Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China;Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China;MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| Abstract: | |
| Keywords: | metabolomics UPLC-MS Radix Paeoniae Rubra Radix Paeoniae Alba anti-platelet |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |