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| 食管鳞癌中CD44H、P-选择素和血管内皮生长因子的表达与淋巴结转移的关系 | |
| 引用本文： | 李娜,李继煜,张景航,王洪兴,焦云娟.食管鳞癌中CD44H、P-选择素和血管内皮生长因子的表达与淋巴结转移的关系[J].新乡医学院学报,2006,23(5):467-469. |
| 作者姓名： | 李娜 李继煜 张景航 王洪兴 焦云娟 |
| 作者单位： | 1. 新乡医学院病理学教研室 2. 新乡医学院国际教育学院 3. 新乡医学院临床免疫学教研室,河南,新乡,453003 |
| 摘 要： | 目的探讨CD44H、P-选择素(P-selectin)和血管内皮生长因子(VEGF)的表达与食管鳞癌淋巴结转移的关系。方法采用免疫组织化学SP法检测60例食管鳞癌组织中CD44H、P-selectin和VEGF的表达。结果淋巴结转移组CD44H、P-selectin和VEGF的表达增强,与无淋巴结转移组的表达差异有显著性意义(P<0.05),P-selectin和VEGF在淋巴结转移组的表达呈正相关(P<0.05)。结论CD44H、P-selectin和VEGF的表达与食管鳞癌淋巴结的转移密切相关,P-selectin和VEGF存在协同关系,可作为评估食管鳞癌预后的生物学标志。 |
| 关 键 词： | 食管鳞癌 粘附分子 P-选择素 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1004-7239（2006）05-0467-03 |
| 收稿时间： | 2006-01-06 |
| 修稿时间： | 2006-01-06 |
Relationship between the expressions of CD44H, p-selectin and VEGF and the metastasis with lymph node in esophageal squamous cell carcinoma |
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| LI Na, LI Ji- yu , ZHANG Jing- hang, et al.Relationship between the expressions of CD44H, p-selectin and VEGF and the metastasis with lymph node in esophageal squamous cell carcinoma[J].Journal of Xinxiang Medical College,2006,23(5):467-469. | |
| Authors: | LI Na LI Ji- yu ZHANG Jing- hang |
| Institution: | 1. Department of Pathology, Xinxiang Medical College, Xinxaing 453003, China ; 2. Department of International Education, Xinxiang Medical College, Xinxiang 453003, China |
| Abstract: | Objective To investigate the relationship of expressions of CD44H,P-selectin and VEGF and lymph node metastasis in patients with esophageal squamous cell carcinoma.Methods Immunohistochemical staining(SP method) was used to detect the expressions of CD44H,P-selectin and VEGF in 60 cases of esophageal carcinoma.Results CD44H,P-selectin and VEGF expressed highly in group with lymph node metastasis. There was a significant difference between the group with and without lymph node metastasis in esophageal squamous cell carcinoma(P<0.05).The expression of P-selectin was positively correlated with the expression of VEGF in group with lymph node metastasis(P<0.05).Conclusion It is closely correlated between the expressions of CD44H,P-selectin and VEGF,and metastasis with lymph node in esophageal squamous cell carcinoma,which might be served as biologic markers for assessment of the prognosis of esophageal carcinoma. |
| Keywords: | esophageal squamous cell carcinoma CD44H P-selectin vascular endothelial growth factor immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |