| 青蒿素增敏复方抑制肿瘤细胞增殖及延缓荷瘤裸鼠移植肿瘤生长的研究 |
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| 引用本文： | 黄玲,张平祖,曾庆平. 青蒿素增敏复方抑制肿瘤细胞增殖及延缓荷瘤裸鼠移植肿瘤生长的研究[J]. 广州中医药大学学报, 2010, 27(3): 254-257,318 |
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| 作者姓名： | 黄玲 张平祖 曾庆平 |
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| 作者单位： | 广州中医药大学学报编辑部,广东广州,510405;广州中医药大学热带医学研究所,广东广州,510405 |
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| 摘 要： | [目的]提高青蒿素抗肿瘤效率,阐明青蒿素增敏复方的抑瘤增敏机理.[方法]采用四甲基偶氮唑盐(MTT)法测定各药物对人肝癌细胞株HepG2细胞的生长抑制率;经皮下接种HepG2细胞进行荷瘤裸鼠造模,测定给药15 d后瘤体质量,计算抑瘤率.[结果]青蒿琥酯配伍马来酸二乙酯、巯基琥珀酸和氨基三唑后,肿瘤细胞的生长抑制率较相同浓度的青蒿琥酯单方高43.84%,抑瘤率较青蒿琥酯单方提高近3倍.HepG2细胞中抗氧化剂含量及抗氧化酶活性测定结果表明,空白组的测定值均高于单方组和复方组,而复方组的测定值低于单方组.[结论]青蒿素增敏复方可能通过降低抗氧化剂含量及抑制抗氧化酶活性发挥抗肿瘤增敏作用.
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| 关 键 词： | 青蒿素/药理学 肿瘤/中西结合疗法 增敏 细胞培养 疾病模型 动物 裸鼠 |
Studies on Artemisinin Sensitizing Compound in Inhibiting Tumor Cell Proliferation and Suppressing Transplanted Tumor Growth in Tumor-bearing Nude Mice |
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| HUANG Ling,ZHANG Pingzu,ZENG Qingping. Studies on Artemisinin Sensitizing Compound in Inhibiting Tumor Cell Proliferation and Suppressing Transplanted Tumor Growth in Tumor-bearing Nude Mice[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2010, 27(3): 254-257,318 |
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| Authors: | HUANG Ling ZHANG Pingzu ZENG Qingping |
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| Affiliation: | HUANG Ling1,ZHANG Pingzu2,ZENG Qingping2(1.Editorial Dept.of Journal of Guangzhou University of TCM,Guangzhou 510405 Guangdong,China,2.Tropical Medicine Institute,Guangzhou University of TCM,China) |
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| Abstract: | Objective To enhance the anti-tumor efficiency of artemisinin and to explore the anti-tumor and sensitivity-enhancing mechanism of Artemisinin Sensitizing Compound(ASC).Methods The growth-inhibition rate of HepG2 cells was determined by methyl thiazolyl tetrazolium(MTT) method.Tumor-bearing nude mice were given inoculation of HepG2 cells subcutaneously.After treatment for 15 days,the tumor-inhibition rate was calculated according to the tumor mass weight.Results The growth-inhibition rate of tumor cells in ... |
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| Keywords: | ARTEMISININ/pharmacology NEOPLASMS/TCM-WM therapy SENSITIZATION CELL CULTURE DISEASE MODELS ANIMAL NUDE MICE |
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