| 染料木素7,4’-硝氧基丁酸酯的合成及其对MC3T3-E1细胞的增殖作用 |
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| 引用本文： | 王捷频,尚福军,王四旺.染料木素7,4’-硝氧基丁酸酯的合成及其对MC3T3-E1细胞的增殖作用[J].解放军药学学报,2010,26(2):107-109,153. |
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| 作者姓名： | 王捷频 尚福军 王四旺 |
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| 作者单位： | 1. 第四军医大学药学系药物研究所,陕西西安,710032
2. 第四军医大学唐都医院心内科,陕西西安,710038 |
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| 摘 要： | 目的为改善染料木素的治疗效果,对其进行结构修饰。方法通过成酯、硝基化反应,在染料木素的7-位,4’-位进行修饰,得到一个硝基酯类化合物;并考察得到的化合物对MC3T3-E1细胞的促增殖作用。结果得到的化合物经核磁、质谱等结构鉴定与设计目标一致。该化合物能够显著促进MC3T3-E1细胞的增殖,且呈一定的时间、剂量依赖关系。结论染料木素7,4’-硝氧基丁酸酯较母体药物更好地促进成骨细胞的增殖,为骨质疏松症治疗药物的开发提供新的参考。
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| 关 键 词： | 染料木素 合成 MC3T3-E1细胞 药理作用 |
Synthesis of Genistein (7,4'- nitrooxybutyrate) and its Proliferation Effects on MC3T3-E1 Cells |
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| WANG Jie-pin①,SHANG Fu-jun②,WANG Si-wang.Synthesis of Genistein (7,4'- nitrooxybutyrate) and its Proliferation Effects on MC3T3-E1 Cells[J].Pharmaceutical Journal of Chinese People's Liberation Army,2010,26(2):107-109,153. |
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| Authors: | WANG Jie-pin① SHANG Fu-jun② WANG Si-wang |
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| Institution: | ①①Institute of Materia Medica, School of Pharmacy, FMMU, Xi’an 710032,China;②Department of Cardiology, Tangdu Hospital, FMMU, Xi’an 710038,China |
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| Abstract: | Objective To improve the efficacy of genistein by modifying its structure. Methods The 7,4’-OH of genistein was modified by esterification and nitration to obtain a nitryl ester compound. The effect of the new product on MC3T3-E1 cells was also observed. Results The obtained compound was exactly the one we had designed. It significantly promoted cell prolification in a time- and dose-dependent manner. Conclusion Genistein （7,4’- nitrooxybutyrate） shows better effect on cell proliferation than its parent drugs. The synthesis of genistein （7,4’- nitrooxybutyrate） may afford a new method in developing antiosteoporosis drugs. |
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| Keywords: | genistein synthesis MC3T3-E1 cells pharmacological effects |
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