氨磺必利和舒必利治疗女性精神分裂症的临床效果比较

目的总结分析氨磺必利和舒必利治疗女性精神分裂症的临床效果。方法选择2013年1月～2013年12月本院收治的80例女性精神分裂症患者为研究对象,随机分为观察组和对照组,各40例,观察组给予氨磺必利治疗,对照组给予舒必利治疗,治疗2个月后,比较两组的治疗效果和不良反应。结果观察组的有效率87.50%,对照组为85.00%,两组比较差异无统计学意义（P〈0.05）;两组治疗后的PANSS评分均明显低于治疗前（P〈0.05）,但两组治疗后的PANSS评分比较差异无统计学意义（P〈0.05）;观察组的不良反应发生率为10.00%,明显低于对照组的37.50%（P〈0.05）。结论氨磺必利与舒必利对女性精神分裂症的治疗效果相当,但舒必利的不良反应发生率较高,临床要慎重选择用药。

Comparison of clinical effect of amisulpride and sulpiride in the treatment of women with schizophrenia

Objective To investigate and analyze clinical effect of amisulpride and sulpiride in treatment of women with schizophrenia. Methods 80 female patients with schizophrenia in our hospital from June January 2013 to December 2013 were divided into the observation group（n=40） and the control group（n=40）.The observation group was given amisulpride,the control group was given sulpiride. After 2 months treatment,the therapeutic effect and adverse reactions of the two groups were compared. Results The effective rate of the observation group was 87.50%,and it was 85.00% in the control group,and there was no statistical difference of the two groups（P〉0.05）;the PANSS score of the two groups were significantly lower than that before treatment（P〈0.05）,but there was no statistical difference of the PANSS score after treatment in the two groups（P〉0.05）;the incidence rate of adverse reaction in the observation group（10.00%） was significantly lower than that of the control group（37.50%）（P〈0.05）. Conclusion Amisulpride and sulpiride in treatment of female schizophrenia has same efficacy, but sulpiride has a higher incidence rate of adverse reaction,clinical medication should be carefully chosen.