α‐Glucosidase Inhibitors from the Stems of Embelia ribes |
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| Authors: | Phu Hoang Dang Hai Xuan Nguyen Nhan Trung Nguyen Hanh Ngoc Thi Le Mai Thanh Thi Nguyen |
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| Affiliation: | 1. Faculty of Chemistry, University of Science, Vietnam National University, , Hochiminh City, Vietnam;2. School of Education, An Giang University, , An Giang, Vietnam |
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| Abstract: | ![]()
From the ethyl acetate extract of the stems of Embelia ribes (Myrsinaceae), a new alkenylresorcinol, embeliphenol A (1), together with 11 known compounds have been isolated. Their structures were elucidated on the basis of spectroscopic data. All compounds possessed significant α‐glucosidase inhibitory activity in a concentration‐dependent manner, except for 2 and 9. Compounds 1, 3–6, 8, and 12 showed more potent inhibitory activity, with IC50 values ranging from 10.4 to 116.7 μM, than that of a positive control acarbose (IC50, 214.5 μM). Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | Embelia ribes embeliphenol A α ‐glucosidase inhibition |
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