| 白细胞介素-1与原发性肾病综合征的关系 |
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| 引用本文： | 向龙,付雪梅,卓平辉,毛萌,杨涛,王伟光,周斌.白细胞介素-1与原发性肾病综合征的关系[J].实用儿科临床杂志,2005,20(5):410-411. |
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| 作者姓名： | 向龙 付雪梅 卓平辉 毛萌 杨涛 王伟光 周斌 |
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| 作者单位： | 1. 广东省妇幼保健院,广东省妇女儿童医院,广州,510010
2. 四川大学华西第二医院儿科,成都,610041 |
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| 摘 要： | 目的探讨白细胞介素-1(IL—1)与原发性肾病综合征(PNS)间的关系。方法采用ELISA法测定PNS患儿急性期和缓解期血清IL-1水平,分析与24 h尿蛋白定量间的关系。结果PNS患儿急性期和缓解期血清IL-1水平比较有显著差异(P<0.01),急性期肾炎型肾病组(NN)血清IL—1高于单纯型肾病组(SN)(P<0.01)。PNS血清IL-1水平与24 h尿蛋白排泄量间呈明显正相关(r=0 758 P<0.01)。结论PNS患儿血清IL-1水平是升高的,IL-1可能在PNS发病中起部分作用。
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| 关 键 词： | 白细胞介素-1 肾变病综合征 原发性 儿童 |
| 文章编号： | 1003-515X(2005)05-0410-02 |
| 修稿时间： | 2005年3月1日 |
Relationship between Interleukin-1 Level of Serum and Primary Nephrotic Syndrome in Children |
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| XIANG Long,FU Xue-mei,ZHUO Ping-hui,MAO Meng,YANG Tao,WANG Wei-guang,ZHOU Bin.Relationship between Interleukin-1 Level of Serum and Primary Nephrotic Syndrome in Children[J].Journal of Applied Clinical Pediatrics,2005,20(5):410-411. |
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| Authors: | XIANG Long FU Xue-mei ZHUO Ping-hui MAO Meng YANG Tao WANG Wei-guang ZHOU Bin |
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| Abstract: | Objective To investigate the relationship between interleukin-1 (IL-1) and pathogenesis of primary nephrotic syndrome (PNS) in children. Methods IL-1 level of serum was measured by enzyme-linked immunosorbent assay(ELISA) in children with PNS who were in active and stable phase and the correlations between IL-1 and urinary protein in 24 hours were analyzed respectively. Results IL-1 level of serum in active phase was significantly higher than that in the stable phase in children with PNS(P< 0.01). IL-1 level of serum in the active phase in NN was significantly higher than that of the stable phase in SN There was a positive correlation between IL-1 level of serum and the excretion of urinary protein in 24 hours( r = 0. 758 P<0.01) Conclusions The IL-1 level in serum is increased in PNS children. IL-1 may play a partial role in the pathogenesis of PNS. |
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| Keywords: | interleukin-1 primary nephrotic syndrome children |
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