| 氧化苦参碱对豚鼠心室肌细胞钠电流的影响 |
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| 引用本文： | 陈霞,李英骥,张文杰,葛敬岩,钟国赣. 氧化苦参碱对豚鼠心室肌细胞钠电流的影响[J]. 吉林大学学报(医学版), 2001, 27(1): 41-42 |
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| 作者姓名： | 陈霞 李英骥 张文杰 葛敬岩 钟国赣 |
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| 作者单位： | 吉林大学基础医学院药理教研室,;吉林大学基础医学院生理教研室 |
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| 摘 要： | 目的 :观察氧化苦参碱 (OMT)对豚鼠心室肌细胞钠电流的影响。方法 :采用全细胞膜片钳技术。结果 :OMT 0 .1、0 .3和 1mmol/ L对钠电流均呈现不同程度的抑制作用 ,且呈现剂量依赖性。结论 :OMT对钠通道的阻滞作用可能是其抗心律失常的作用机制之一。
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| 关 键 词： | 氧化苦参碱 膜片钳 钠电流 心室肌细胞 |
| 文章编号： | 0253-3707(2001)01-0041-02 |
| 修稿时间： | 2000-03-09 |
Effects of oxymatrine on sodium current in isolated ventricular cells in guinea-pig |
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| CHEN Xia,LI Ying-ji,ZHANG Wen-jie,GE Jing-yan,ZHONG Guo-gan. Effects of oxymatrine on sodium current in isolated ventricular cells in guinea-pig[J]. Journal of Jilin University: Med Ed, 2001, 27(1): 41-42 |
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| Authors: | CHEN Xia LI Ying-ji ZHANG Wen-jie GE Jing-yan ZHONG Guo-gan |
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| Affiliation: | CHEN Xia 1,LI Ying ji 2,ZHANG Wen jie 2,GE Jing yan 2,ZHONG Guo gan 2 |
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| Abstract: | Objective:Effects of oxymatrine on the sodium current were studied .Methods:The whole cell voltage clamp technique was used in isolated ventricular cells of guinea-pig.Results:Oxymatrine (0.1,0.3 and 1 mmol/L) showed inhibition to the sodium current in dose-dependence.Conclusion:These results indicate that inhibition of oxymatrine to the sodium current may be one of mechanisms of its antiarrhythmic action. |
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| Keywords: | ? oxymatrine patch clamp sodium current guinea pig ventricular cells |
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