| 系统性红斑狼疮患者CD28表达及其意义 |
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| 引用本文： | 邓安梅,陈孙孝,仲人前,张玲珍,孔宪涛. 系统性红斑狼疮患者CD28表达及其意义[J]. 基础医学与临床, 2000, 20(4): 40-41 |
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| 作者姓名： | 邓安梅 陈孙孝 仲人前 张玲珍 孔宪涛 |
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| 作者单位： | 上海第二军医大学附属长征医院,全军临床免疫中心;上海第二军医大学附属长征医院,皮肤科,上海200003 |
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| 摘 要： | ＣＤ２８是Ｔ细胞激活中重要的共刺激分子。为了解Ｂ７－Ｃ礤刺激途径在系统性红斑狼疮（ＳＬＥ）中的作用,我们对３０例期ＳＬＥ２外周血Ｔ细胞ＣＤ２８的表达进行了检测,并分析了其激活后凋亡情况。结果表明,ＳＬＥ组的ＣＤ２８Ｔ细胞低于正常对照组,在抗ＣＤ３单抗刺激后ＣＤ２８细胞凋亡率增加。这提示ＳＬＥ中Ｂ７－ＣＤ２８共刺激途径介导的ＡＩＣＤ可能导致ＳＬＥ中的Ｔ细胞淋巴细胞贫血症。
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| 关 键 词： | 系统性红斑狼疮 CD28 |
| 修稿时间： | 1998-12-17 |
CD28 expression on Tcell subsets in patients with systemic lupus erythematosus |
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| DENG An-mei,CHEN Sun-xiao,ZHONG Ren-qian,et al. CD28 expression on Tcell subsets in patients with systemic lupus erythematosus[J]. Basic Medical Sciences and Clinics, 2000, 20(4): 40-41 |
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| Authors: | DENG An-mei CHEN Sun-xiao ZHONG Ren-qian et al |
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| Abstract: | In view of the role of B7-CD28 costilllulatory pathway in SLE, we examined CD28 expression on T cell in patients with systemic lupus erythematosus and AICD. The results show CD28 cell in SLE group was decreased and its apoptosis accelerated under stimulating with anti-CD3 McAb. It suggest that CD28-mediated costimulation influence T cell SLlsceptibility to AICD and may be involved in T cell Lymphopenia in SLE. |
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| Keywords: | SLE CD28 |
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