| 慢性乙醇中毒小鼠海马Caspase-3的表达 |
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| 引用本文： | 亢勤.慢性乙醇中毒小鼠海马Caspase-3的表达[J].郑州大学学报(医学版),2011,46(5):754-756. |
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| 作者姓名： | 亢勤 |
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| 作者单位： | 河南省建筑医院内科 郑州450001 |
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| 摘 要： | 目的:探讨慢性乙醇中毒小鼠海马Caspase-3的表达.方法:小鼠随机分为3组,正常对照组,高、低剂量乙醇组,每组6只,雌雄各半.高、低剂量组分别灌胃2.4和4.8 mL/d无水乙醇,以建立慢性酒精中毒小鼠模型;正常对照组灌胃等量生理盐水.采用Morris型水迷宫实验检测小鼠学习记忆功能;出现学习记忆功能障碍2周后免疫...
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| 关 键 词： | 慢性乙醇中毒 Caspase-3 小鼠 |
Expression of Caspase-3 in hippocampus of chronic alcoholic dementia mice |
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| KANG Qin.Expression of Caspase-3 in hippocampus of chronic alcoholic dementia mice[J].Journal of Zhengzhou University: Med Sci,2011,46(5):754-756. |
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| Authors: | KANG Qin |
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| Institution: | KANG Qin Department of Internal Medicine,Building Hospital of Henan Province,Zhengzhou 450001 |
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| Abstract: | Aim:To study the expression of Caspase-3 in hippocampus of chronic alcoholic dementia mice.Methods:Mice were allocated in 3 groups:normal control group,high-dose and low-dose alcohol group,and 6 in each group.The mice in high-dose and low-dose group were given intragastricly 4.8 and 2.4 mL/d absolute ethyl alcohol to establish chronic alcoholic dementia model.The learning-memory function was detected by Morris water maze experiment,and 2 weeks later,immunohistochemical staining and Western-blotting were use... |
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| Keywords: | chronic alcoholic dementia Caspase-3 mouse |
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