| 热休克蛋白70与加速度应激 |
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| 引用本文： | 韦应波,孙喜庆,吴兴裕.热休克蛋白70与加速度应激[J].航天医学与医学工程,2001,14(6):460-464. |
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| 作者姓名： | 韦应波 孙喜庆 吴兴裕 |
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| 作者单位： | 第四军医大学航空航天医学系航空航天生物动力学教研室, |
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| 摘 要： | 现代高性能战斗机产生的高G值持续性正加速度可导致脑缺血、缺氧，继而引起脑功能障碍。热休克蛋白70（heat shock protein 70,HSP70）是生物体中广泛存在的一种蛋白质，其表达与脑缺血中的应激反应有重要关系，与神经细胞的缺血性损伤密切相关，目前大多数研究认为应激时HSP70的表达对神经元有保护作用。本文综述了HSP70的生物学特性及其在脑缺血后对细胞保护作用，并阐述了HSP70的表达与＋Gz暴露强度的关系。
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| 关 键 词： | 正加速度 应激 热休克蛋白70 意识丧失 航空医学 |
| 文章编号： | 1002-0837(2001)06-0460-05 |
| 修稿时间： | 2001年1月9日 |
Heat Shock Protein 70 and Stimulation Induced by + Gz. |
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| WEI Ying bo,SUN Xi qing,WU Xing yu.Heat Shock Protein 70 and Stimulation Induced by + Gz.[J].Space Medicine & Medical Engineering,2001,14(6):460-464. |
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| Authors: | WEI Ying bo SUN Xi qing WU Xing yu |
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| Institution: | Department of Aerospace Biodynamics, The Fourth Military Medical University, Xi'an, China. |
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| Abstract: | High sustained +Gz acceleration produced by modern high performance aircrafts can induce brain damage because of ischemia and hypoxia. Heat shock protein 70(HSP70)is one of the proteins broadly exist in organisms. The expression of HSP70 is an important reaction in the brain, and it has close relationship with brain ischemic injury. Now, the common view thinks that the expression of HSP70 during stimulation can protect nerve cells. This paper reviewed the biologic characteristics of HSP70 and the protective effect of HSP70 on nerve cells after brain ischemia. Also, the relationship of HSP70 expression and exposure value of +Gz were discussed. |
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| Keywords: | Gz stress heat shock protein 70 G LOC |
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