尼麦角林在脑血管病中的应用

尼麦角林是一种麦角生物碱衍生物，广泛应用于脑血管病患者认知障碍的治疗。多项临
床前研究显示，尼麦角林对于认知障碍的改善可能与以下因素有关：尼麦角林除能够改善脑循环，
促进神经递质释放外，还具有营养神经及抗氧化等作用。目前的研究认为，尼麦角林能够改善患者
卒中后抑郁相关的情绪障碍以及有效改善血管性痴呆，提高患者的日常生活能力。同时，尼麦角林具
有良好的安全性，目前暂无尼麦角林治疗导致纤维化或麦角中毒的研究报道。本文就尼麦角林在神
经系统的作用机制、临床疗效及安全性进行综述，以期为临床应用提供参考。

Application of Nicergoline in Cerebrovascular Disease

Nicergoline is an ergot derivative, which is widely used in the treatment of cognitive
impairment in patients with cerebrovascular disease. Preclinical studies suggested the mechanisms
of nicergoline in improving cognitive deficits may be related to the following factors: improve
cerebral blood flow, promote neurotransmitters releasing, neurotrophic and antioxidant effect.
Current studies suggested that nicergoline can improve post-stroke depression, vascular cognitive
impairment and dementia. Nicergoline has a good safety profile, and up to now none of the studies
reported any incidence of fibrosis or ergotism after taking nicergoline. This article reviewed the
mechanism, clinical efficacy and safety of nicergoline in nervous system, to provide reference for
clinical application.