HIV／AIDS患者CD4^＋、CD8^＋及WBC检测分析

目的分析HIV／AIDS患者外周血T辅助细胞（CD4^＋）、T抑制细胞（CD8^＋）和白细胞（WBC）检测结果。方法CD4^＋和CD8^＋计数通过免疫荧光标记，采用流式细胞仪检测；白细胞（WBC）计数采用全自动细胞分析仪检测。结果118例HIV／AIDS住院患者，WBC降低组（3．00±0．61）×10^9/L的CD4^＋和CD8^＋分别为（68．60±38．98）个/ul和（266．89±126．52）处／ul，WBC正常组（7．13±5．12）×10^9／L的CD4＋和CD8＋分别为（104．39±61．37）个/ul和（380．17±134．06）个/ul，两者差异有统计学意义（t1＝5．78，守3．62，t3=5．35，P均〈0．01）；两组别CD4^＋／CD8^＋比值比较均呈有统计学意义（P〈0．05）。结论HIV，AIDS患者在发病过程中与CD4^＋、CD4^＋／CD8^＋、WBC有密切相关，建议HIV感染者尽早进行医学咨询并做CD4^＋、CD8^＋和血常规的检测，以了解病情的进展及进行抗病毒治疗。

Detection of CD4~+,CD8~+ and WBC from HIV/AIDS patients

Aim Analysis the relevance of peripheral T helper cell （CD4^＋）,T inhibited cell （CD8^＋）count and white blood cell （WBC） testing results of 118 cases of HIV/AIDS patients in our hospital. Methods CD4^＋ and CDS^＋ T iymphoeyte count are detected by flow cytometty,white blood cell（WBC） count is detected by cell analyzer. Results （1） In 118 eases of HIV / AIDS in hospitalized patients,CD4^＋ and CD8^＋ of WBC reduction group （3.00±0.61）×10^9/L are respectively （68.6±38.98）/ul and （266.89±126.52）/ul. CD4＋ and CD8＋ of WBC normal group （7.13±5.12）×10^9/L are respectively （104.39±61.37）/ul and （380.17±134.06）/ul. The both difference has statistics significance,see Table 1 （tl= 5.78,t2= 3.62,t3= 5.35 P〈0.01 ）. （2） CD4^＋values are divided into different group （see Table 2）. Each group comparison with CD4^＋/CD8^＋ ratio shows signlficandy correlation,the correlation coefficient is respectively 0.586,0.698 and 0.409 （P〈 0.05）. Conclusion It is closely related that HIV/AIDS patients in the disease process and the CD4^＋,CD8^＋,WBC. HIV infection are recommended medical advice as soon as possible,understand the progress of the disease and treat antiviral in time by CD4^＋, CD8^＋ and blood routine testing. HIV/AIDS patients in the course of treatment should be CD4^＋, CD8^＋ and blood routine testing for regular.