液基薄层细胞学联合阴道镜筛查宫颈病变结果分析

目的评价液基薄层细胞学（TCT）检查与阴道镜下活检，进行病理组织学检查，在宫颈病变诊断中的价值。方法对2009年11月～2010年10月在三亚市妇幼保健院门诊与妇科体检的4860例患者做TCT检查。细胞学诊断采用TBS分级系统，将不典型鳞状细胞（ASCUS）以上病变均列为阳性病例，对阳性病例进一步采用阴道镜下活检。结果4860例TCT诊断阳性患者446例占9．17％，其中ASCUS361例占7．43％，低度鳞状上皮内病变（LSIL）70例占1．44％。高度鳞状上皮内病变（HSIL）11例占0．22％，鳞状细胞癌（SCC）4例占0．08％。阳性病例全部在阴道镜下取活检。病理组织学诊断宫颈上皮内瘤变（CIN）197例，其中CINI169例，CINII20例，CINIII8例。原位癌1例，SCC7例，宫颈炎症241例。结论TCT用于宫颈早期病变的筛查是目前最好的筛查方法，而TCT联合阴道镜下活检可提高宫颈病变的检出率及准确率。

Study on the utilization of foliate by gravidae detected with FQ-PCR

Aim To investigate the utilization of foliate by the gravidae with history of gestational and lying-in problems and offer scientific basis for improving the population quality.Methods The polymorphism of genotypes of 5,10-methylenetetrahydrofolate reductase(MTHFR),Methionine synthase reductase(MTSRR)and A1298C were determined by fluorescnet uantitative polymoerase chain reaction(FQ_PCR) and the utilization ability of folate by the gravidae was graded and analyzed.Results The frequencies of MTHFR 677TT a gen...