不同分子亚型乳腺癌与腋窝淋巴结转移的相关性分析

目的探讨乳腺癌不同分子亚型与腋窝淋巴结转移的关系。方法对127例乳腺癌患者进行分子分型,并对其腋窝淋巴结转移状态进行分析。结果 127例中Luminal A型50例,8例淋巴结转移,转移率为16.0%;Luminal B1型28例,16例淋巴结转移,转移率为57.1%;Luminal B2型15例,3例淋巴结转移,转移率为20.0%;HER-2过表达型25例,7例淋巴结转移,转移率为28.0%;Basal-like型9例,6例淋巴结转移,转移率为66.7%。结果显示,不同分子分型乳腺癌的腋窝淋巴结转移阳性率差异显著。结论根据乳腺癌的分子分型可以间接了解患者腋窝淋巴结的转移情况,或对腋窝淋巴结清扫术指征的制定提供帮助。

Correlation analysis on different molecular subtypes of breast cancer and axillary lymph node metastasis

Objective To discuss the correlation between different molecular subtypes of breast cancer and axillary lymph node metastasis. Methods We made molecular classification on 127 cases of patients with breast cancer,and analyse axillary lymph node metastasis status. Results There were 50 Luminal cases in which 8 （ 16. 0% ） were found to be axillary lymph nodes metastasis; among the 28 Luminal B1 cases,there were 16 （ 57. 1% ） axillary lymph nodes metastasis; among the 15 Luminal B2 cases,there were 3（ 20. 0% ） axillary lymph nodes metastasis; there were 7 cases （ 28. 0% ） of axillary lymph nodes metastasis in the 25 cases of HER-2（＋） subtype; and in the 9 cases of Basal-like subtype,6（ 66. 7% ） were axillary lymph nodes metastasis. There were statistically significant differences between positive rates of axillary lymph node metastasis（ P 0. 05） . Conclusions According to the molecular classification of breast cancer,the metastasis of axillary lymph node can be indirectly understood,or the establishment of axillary lymph node dissection indications could provide help.