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| 三七总皂苷/山茱萸总皂苷组分对犬冠状动脉结扎缺血心肌的保护作用研究 | |
| 引用本文： | 唐志书,郭立玮,王斌,宋延平. 三七总皂苷/山茱萸总皂苷组分对犬冠状动脉结扎缺血心肌的保护作用研究[J]. 时珍国医国药, 2011, 22(1): 72-74. DOI: 10.3969/j.issn.1008-0805.2011.01.031 |
| 作者姓名： | 唐志书 郭立玮 王斌 宋延平 |
| 作者单位： | 1. 陕西中医学院,陕西,咸阳,712046;南京中医药大学,江苏,南京,210015 2. 南京中医药大学,江苏,南京,210015 3. 陕西中医学院,陕西,咸阳,712046 |
| 基金项目： | 国家"十一五"科技支撑项目，陕西省科技计划项目[No |
| 摘 要： | 目的观察三七总皂苷/山茱萸总苷组分(PNS/TGCO)不同剂量对犬冠状动脉结扎造成心肌梗塞模型的保护作用。方法杂种犬随机分为模型对照组,PNS/TGCO大(40 mg/kg)、中(20 mg/kg)、小(10 mg/kg)剂量组、血塞通胶囊组(20mg/kg)。采用结扎麻醉犬冠状动脉左前降支造成急性心肌缺血梗塞损伤,十二指肠给药后,可显著减少冠脉结扎所致的∑-ST、N-ST抬高,用硝基四氮唑蓝染色,观察心脏梗塞范围,检测血清中肌酸磷酸激酶(CPK)和乳酸脱氢酶(LDH)活性的变化。结果 PNS/TGCO组分大、中组可显著降低犬冠脉结扎后心肌缺血的程度,缩小心肌缺血的范围;显著降低犬冠脉结扎后血清LDH、CPK活性。结论 PNS/TGCO组分对急性心肌缺血犬具有明显的保护作用。 |
| 关 键 词： | 三七总皂苷/山茱萸总苷 心肌缺血 冠状动脉结扎 |
Protective Effect of PNS/TGCO on Ligation - induced Acute Myocardial Ischemia in Anesthetized Dogs |
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| TANG zhi-shu,GUO Li-wei,WANG Bin,SONG Yan-ping. Protective Effect of PNS/TGCO on Ligation - induced Acute Myocardial Ischemia in Anesthetized Dogs[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(1): 72-74. DOI: 10.3969/j.issn.1008-0805.2011.01.031 | |
| Authors: | TANG zhi-shu GUO Li-wei WANG Bin SONG Yan-ping |
| Affiliation: | 1(1.Shanxi University of Chinese Medicine,Xianyang 712046,China;2.Nanjing University of Chinese Medicine,Nanjing 210015,China) |
| Abstract: | Objective To observe the protective effect of Panax notoginseng saponins(PNS) and total saponins from Cornus officinalis(TGCO) components on myocardial ischemia dogs.Methods In left coronary artery ligation model,infarction range,△Σ-ST and some serum indexes(such as CPK,LDH) was measured after ig PNS/TGCO(40,20,10 mg·kg-1).Results Large and middle doses of PNS / TGCO components could significantly inhibit the increase of △Σ-ST and N-ST,reduce the size of myocardial ischemia,decrease the contents of LDH,CPK in serum in dogs after coronary artery ligation.Conclusion PNS / TGCO components has protective effect on acute myocardial ischemic dogs. |
| Keywords: | Panax notoginseng saponins(PNS)/Total saponins from Cornus officinalis(TGCO) Myocardial ischemia Coronary artery ligation |
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