静脉注射三乙醇胺对Beagle犬的病理性损伤作用

目的 观察静脉注射三乙醇胺后Beagle犬的组织病理学改变及其可逆性。方法 Beagle犬12只，分为对照组和150 mg/kg剂量组，连续给药30 d和恢复4周后，分别进行大体解剖和组织病理学检查。结果 连续给药30 d，Beagle犬出现肝细胞变性、坏死，及肝窦扩张，网状纤维蛋白样物质沉积；肾脏髓质和皮髓交界处肾小管上皮细胞变性；脾脏、淋巴结和肠黏膜相关淋巴组织内淋巴滤泡数量增多，生发中心增大，脾小体帽区局灶性坏死，其中雌性动物肝脏、脾脏病变程度较雄性严重。经过4周恢复，肝脏、脾脏、肾脏、淋巴结、肠黏膜相关淋巴组织病变恢复不明显。结论 静脉注射一定剂量的三乙醇胺，可能对肝脏、肾脏、脾脏、淋巴结以及肠黏膜相关淋巴组织有一定的损伤作用。

The Pathological Damage of Beagle Dog after Intravenous Injection of Trolamine

Objective Histopathology change of Beagle dog and its recoverability are observed after trolamine iv. Methods Twelve Beagle dogs are divided into control group and 150 mg/kg dosage group, gross anatomy and Histopathology observation are put into practice after the continuous administration for 30 days and the recovery for 4 weeks. Results Some tissue structure of Beagle dogs via 30 d successive administration, such as liver, kidney, spleen, lymph node and intestinal mucosa-related lymphatic tissue, are changed.Hepatocyte degeneration and necrosis, expansion of hepatic sinus and deposition of reticular fibrin-like substance occur in liver. Part epithelial cell degeneration of renal tubule appears in medulla and juncture of it and cortex in kidney. Spleen shows germinal center increase and focal necrosis of its cap of splenic corpuscle. The number of folliculus lymphaticus and the volume of germinal center in lymph node and intestinal mucosa-related lymphatic tissue rise. The level of the pathological changes in liver and spleen in female animal is more serious than male animal. Conclusion liver, spleen, kidney, lymph nod and intestinal mucosa-related lymphatic tissue can be damaged by trolamine iv.