ICSI-ET黄体中期应用GnRHa对妊娠结局的影响

目的单精子卵胞浆内显微注射-胚胎移植周期中黄体中期应用促性腺素释放激素激动剂（GnRHa）是否提高临床妊娠率。方法 300个单精子卵胞浆内显微注射-胚胎移植周期的病例,随机分为实验组及对照组,移植日为单数日做为实验组,移植后3 d单次皮下注射GnRHa 0.1 mg,对照组不予以注射GnRHa,比较2组患者在GnRHa用药前后血清激素水平、种植率及临床妊娠率的变化。结果实验组临床妊娠率为51.25%,对照组为45.00%;GnRHa组和对照组激素水平、种植率及临床妊娠率相当。结论单精子卵胞浆内显微注射-胚胎移植周期中黄体中期应用GnRHa,其种植率、临床妊娠率、流产率、活胎出生率、卵巢过度刺激综合征（OHSS）没有显著改善。

Effect of luteal-phase gonadotropin-releasing hormone agonist administration on clinical pregnancy rate after intracytoplasmic sperm injection

Objective To evaluate the effect of gonadotropin-releasing hormone（GnRH） agonist,administered in the luteal-phase,on intracy to plasmic sperm injection（ICSI） outcome.Methods 300 intracytoplasmic sperm microinjection-embryo transfer cases were divided into experimental and control groups,transplantation at single days as the experimental group.3 days after transplantation,GnRHa group was given a single subcutaneous injection of 0.1 mg of GnRHa,control group did not.Serum hormone levels,implantation rate and clinical pregnancy rate of change in patients before and after treatment were compared.Results There was 51.25% clinical pregnancy rate in the GnRH agonist group,and 45% in the control group.The rate of implantation, clinical pregnancy,abortion and live birth were similar in the GnRH agonist and control group likewise.Conclusion Luteal-phase GnRH agonist administration does not seem to enhances ICSI clinical outcomes.