国产与进口异氟醚对血流动力学影响的对比研究

目的观察国产与进口异氟醚对血流动力学的影响,并验证国产产品的质量.方法择期手术病人30例,随机分为两组(每组15例),气管插管后置放经食道多普勒探头置于T5-6水平,并朝向降主动脉血流,按随机双盲法分别吸入国产或进口异氟醚.当其最低肺泡有效浓度(MAC)达0.5、1.0和1.5时,分别记录血流动力学各项指标.结果呼末吸入浓度≥0.5MAC时,收缩压、舒张压及平均动脉压均下降(P＜0.05),达1.5MAC时则呈心肌抑制作用.国产与进口产品在相同MAC时,其各项指标均无差异.结论两种异氟醚均呈剂量相关性循环抑制作用,但在同一浓度下二者无差异.说明国产与进口异氟醚质量相当.

The comparison study of influence on hemodynamics between homemade and import isoflurance

Objective: To observe the influence on hemodynamics caused by homemade and import isoflurance, then verify the quality of homemade goods. Methods: Thirty patients undergoing elective procedures were randomly divided into two groups(each group has fifteen patients) After intratracheal intubation, we put the transoesophageal Doppler's probe at five to six theracicae level, and let it face to the descending aorta. The patients inhaled homemade or import isoflurance respectively according to double)-blind principle. Results: The systolic pressure, diastolis pressure and mean atrial pressure went down when the end -expiratory inspiratory concentration greater than 0. 5 MAC(P < 0. 05). When it reached 1. 5 MAC, the myocardiuma were inhibited. At the same MAC, the hemodynamic indexs have not different Conclusion: Two kind isoflurance all have the effects of circulatory inhibition and it was dose-dependent, But at the same concentration, they have not different. It shows the quality of homemade and import isoflurance was match.