| 结直肠癌肝转移的分子机制研究进展 |
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| 引用本文： | 程伏林,熊斌,周云峰. 结直肠癌肝转移的分子机制研究进展[J]. 武汉大学学报(医学版), 2009, 30(2): 272-276 |
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| 作者姓名： | 程伏林 熊斌 周云峰 |
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| 作者单位： | 武汉大学中南医院肿瘤科/肿瘤生物学行为湖北省重点实验室/湖北省肿瘤临床医学研究中心,湖北,武汉,430071;武汉大学中南医院肿瘤科/肿瘤生物学行为湖北省重点实验室/湖北省肿瘤临床医学研究中心,湖北,武汉,430071;武汉大学中南医院肿瘤科/肿瘤生物学行为湖北省重点实验室/湖北省肿瘤临床医学研究中心,湖北,武汉,430071 |
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| 基金项目： | 湖北省自然科学基金项目(编号:2006ABA213) |
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| 摘 要： | 结直肠癌肝转移涉及许多分子机制,参与结直肠癌肝转移的有二十多个分子因子,这些分子因子基于其功能分成4个部分:蛋白质水解、黏附、血管生成和细胞生存。通过理解其中许多复杂的分子机制,有望发现一些新的检测和治疗靶点,以期达到预防转移和提高病人生存率的目的。
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| 关 键 词： | 结直肠癌 肝转移 分子因子 |
Advanced Research on Molecular Mechanisms of Hepatic Metastasis in Colorectal Cancer |
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| CHENG Fulin,XIONG Bin,ZHOU Yunfeng. Advanced Research on Molecular Mechanisms of Hepatic Metastasis in Colorectal Cancer[J]. Medical Journal of Wuhan University, 2009, 30(2): 272-276 |
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| Authors: | CHENG Fulin XIONG Bin ZHOU Yunfeng |
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| Affiliation: | CHENG Fulin,XIONG Bin,ZHOU Yunfeng Dept.of Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
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| Abstract: | This review has identified many recent advances involved in colorectal cancer hepatic metastasis.Twenty molecular factors were identified and included in this review.The molecular factors were separated into four groups based on their functions as proteolysis,adhesion,angiogenesis and cell survival.In order to better understanding the complex molecular events involved in metastasis,novel screening and therapeutic tools may be developed for the ultimate goal of preventing metastasis and increasing survival r... |
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| Keywords: | Colorectal Cancer Hepatic Metastasis Molecular Factors |
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