江苏黄泛平原高碘甲状腺肿地方性流行的证实和流行病学研究

在江苏黄泛平原选点对该地区甲状腺肿的流行原因、流行范围和特征进行了研究 ,结果发现学生甲状腺肿大率 (甲肿率 )触诊法为 2 2 .18% ,B超法为 12 .83% ,均超过有关国际组织提出的地方性甲状腺肿病区甲肿率切点值 5% ;60 7份尿样的碘含量中位数为 962μg/L ;62名健康居民甲状腺 2 4小时摄 131I率平均值为 4 .60 %± 0 .30 % ;血清 TSH、T4 、T3值大多在正常值范围内 ;在调查的 65个乡的 10 4 9份水样中有 771份水样的碘含量超过 30 0μg/L ,52个乡的水碘中位数超过30 0μg/L。结果提示 ,该地区流行的甲状腺肿呈地方性流行 ,由居民饮用碘含量过高的浅层地下水所致 ,高碘水源呈片状分布。

Verif ication and Epidemiological Study on Endemic Iodide-induced Goiter in Jiangsu Old YellowRiver Flooded Plain

To verify the existence and reveal the epidemiological characteristics of endemic iodide-induced goiter in Jiangsu Old Yellow River flooded plain, 12 spots were selected in this survey. The results showed that the total goiter rate of 22.18% by palpation and 12.83% by B-ultrasound which surpassed the 5%-cutpoint-recommended jointly by WHO/UNICEF/ICCIDD. The urinary iodine median was 962 micrograms/L in 607 samples. The average 24 hours I31iodine-emissivity ratio was 4.6 +/- 0.3% with most of the serum TSH, T4, T3 within normal ranges. Of 1049 water samples in 65 towns, 771 had iodine content over 300 micrograms/L with water iodine concentration over 300 micrograms/L in 52 towns. These findings suggested that goiter in this plain had been endemic which related to excessive iodine in shallow well water. Heavy load of iodine over general population was noticed.