| PHLPP在非小细胞肺癌中的表达及临床意义 |
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| 引用本文： | 谢优优,;吕冬青,;杨佩浓,;杨海华. PHLPP在非小细胞肺癌中的表达及临床意义[J]. 中国现代医生, 2014, 0(27): 21-23 |
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| 作者姓名： | 谢优优, 吕冬青, 杨佩浓, 杨海华 |
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| 作者单位： | [1]浙江省台州医院放疗科,浙江临海317000; [2]浙江省台州医院呼吸科,浙江临海317000; [3]浙江省台州医院病理科,浙江临海317000; [4]浙江省台州医院肿瘤细胞和分子放射生物学实验室,浙江临海317000 |
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| 基金项目： | 浙江省医药卫生科技项目（2013KYA225）;浙江省台州市科技局项目（121KY08） |
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| 摘 要： | 目的：探讨PHLPP在非小细胞肺癌（NSCLC）中的表达及临床意义。方法采用免疫组织化学染色的方法检测82例NSCLC组织中PHLPP蛋白的表达情况,并结合临床及病理因素进行相关性分析。结果 PHLPP主要在细胞膜上表达,在NSCLC中63%阴性表达、11%为＋、10%为＋＋、16%为＋＋＋,PHLPP的表达与NSCLC的分化程度存在显著相关性（P=0.024）,与年龄、性别、吸烟状况、病理类型及分期没有显著相关性。结论 PHLPP蛋白在人NSCLC组织中表达率为37%,与NSCLC的分化程度有相关性。
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| 关 键 词： | 非小细胞肺癌 PHLPP 免疫组织化学 |
Clinicopathological correlations of PHLPP expression in non-small cell lung cancer |
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| Affiliation: | XIE Youyou, LV Dongqing, YANG Peinong, YANG Haihua (1.Department of Radiation Oncology, Taizhou Hospital in Zhejiang Province, Linhai 317000, China; 2.Department of Pneumology, Taizhou Hospital in Zhejiang Province, Linhai 317000, China; 3.Department of Pathology, Taizhou Hospi- tal in Zhejiang Province, Linhai 317000, China; 4.Laboratory of Cellular and Molecular Radiation Oncology,Taizhou Hospital in Zhejiang Provinee, Linhai 317000,China) |
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| Abstract: | Objective To investigate the expression of PHLPP in non-small cell lung cancer （NSCLC）and its correla-tions of clinicopathological characteristics. Methods All of 82 tissue specimens with NSCLC were examined with im-munohistochemical staining, and the results of IHC were analyzed with the clinicopathologic characteristics. Results PHLPP mainly expressed on the cell membrane. The rate of PHLPP expression was negative in 63%, poor in 11%, moderate in 10% and strong in 16%, respectively. The expression of PHLPP was significantly correlated with differen-tiation, but not with age, smoking states, pathological type and stage. Conclusion The positive expression rate of PHLPP is 37%in human NSCLC tissue specimens and was correlated with histological differentiation . |
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| Keywords: | Non-small cell lung cancer（NSCLC） PHLPP Immunohistochemistry（IHC） |
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