乙肝基因重组疫苗两种免疫程序接种新生儿3年免疫效果观察

为了解国产乙肝基因重组疫苗免疫效果，我们分别按０、１、２月和０、１、６月免疫程序对７０名新生儿进行了３年免疫效果观察，结果发现有一人次低热（３７．８℃），发热率为０．４８％。其余未见过敏、高热、局部红肿等副反应。新生儿分别按两种免疫程序接种后抗－ＨＢｓ阳转率在３、７、１２、２４、３６月时检测均无显著性差异（Ｐ＞０．０５）。而抗－ＨＢｓ几何平均滴度（ＧＭＴ）在３个月时０、１、２月免疫组（８１．３５）显著高于０、１、６月免疫组（３３．１４），Ｐ＜０．０１，并发现两组免疫程序接种后，７个月左右时抗－ＨＢｓ的ＧＭＴ均达到最高峰，随访到３６个月时抗－ＨＢｓ阳转率和ＧＭＴ仍保持较高水平，且两组间无显著性差异（Ｐ＞０．０５）。说明，两种免疫程序对新生儿抗－ＨＢｓ阳转率和ＧＭＴ的诱导无显著性差异，且０、１、２免疫程序接种时间短，抗体滴度上升快。但需进一步深入研究。

An Observation on 3 years Immunological Effect of Recombinant Hepatitis B Vaccine in Infants

infants were radomly divided into two groups; groupA was inoculated in 0,1,2month after birth,group B in 0,1,6 months after birth.High fever reaction (37.8C) was occurred in only one infant in whole objectives.There was no severe adverse reaction such as allergy,fever,edema in the remained infants.There was no significant difference of positive rates of anti-HBs antibody between two groups at 3,7,12,24 and 36 months after immunization.But the mean geometic titer (GMT) of anti-HBs at the 3 months after Ist dose immunization in group A was significantly higher than that in group B (P<0.001).The GMT of anti-Hbs was reached to the peak in 7 months immunization and those high level of anti-HBs positive rates and GMT of anti-HBs were maintained untill to 36 months post vaccination in both two groups.Also,there was no significant difference of either the anti-HBs positive rate or the GMT of anti-HBs between these two groups.Due to the advantage of shorter time for antibody production ,the authors suggested that people had better to choice the group A scheme.