| 微透析技术在药物靶组织分布和代谢研究中的应用 |
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| 引用本文： | 张丽艳,李范珠.微透析技术在药物靶组织分布和代谢研究中的应用[J].中国新药杂志,2006,15(24):2103-2106,2146. |
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| 作者姓名： | 张丽艳 李范珠 |
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| 作者单位： | 浙江中医药大学药学院,杭州,310053 |
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| 摘 要： | 微透析技术是一项新兴的在体研究技术，近年来已广泛应用于药物在靶组织分布和代谢研究，对于阐明药物体内过程、疗效和安全性有重要意义，为新药研发与临床合理用药提供科学依据。现通过检索分析相关文献，就微透析技术的概况、微透析探针、透析液的分析及微透析技术在药物靶组织分布和代谢研究中的应用作一综述。
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| 关 键 词： | 微透析技术 靶组织 分布 代谢 |
| 文章编号： | 1003-3734（2006）24-2103-05 |
| 收稿时间： | 2006-07-10 |
| 修稿时间： | 2006-07-10 |
Application of microdialysis technique in tissue-targeted distribution and metabolism of drugs |
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| ZHANG Li-yan,LI Fan-zhu.Application of microdialysis technique in tissue-targeted distribution and metabolism of drugs[J].Chinese Journal of New Drugs,2006,15(24):2103-2106,2146. |
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| Authors: | ZHANG Li-yan LI Fan-zhu |
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| Institution: | College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China |
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| Abstract: | Microdialysis technique has become a powerful tool the in situ studies of tissue-targeted distribution and metabolism of pharmaceuticals. It plays an important role in elucidation of pharmacodynamics in vivo, efficacy and safety of drugs, and may provide a strategic direction in the development and clinical rational use of drugs. This review presents the current status of the microdialysis technique including microdialysis probes and the analysis of dialysate in the tissue-targeted distribution and metabolism of drugs. |
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| Keywords: | microdialysis technique tissue-targeted distribution metabolism |
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