Rosiglitazone Attenuates Liver Inflammation in a Rat Model of Nonalcoholic Steatohepatitis |
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| Authors: | Veysel Tahan Fatih Eren Erol Avsar Dilek Yavuz Meral Yuksel Ebru Emekli Nese Imeryuz Cigdem Celikel Hafize Uzun Goncagul Haklar Nurdan Tozun |
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| Affiliation: | (1) Department of Gastroenterology, Marmara University School of Medicine, Istanbul, Turkey;(2) Institute of Gastroenterology, Marmara University, Istanbul, Turkey;(3) Department of Endocrinology, Marmara University School of Medicine, Istanbul, Turkey;(4) Department of Biochemistry, Marmara University School of Medicine, Istanbul, Turkey;(5) Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey;(6) Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey;(7) Cavusdere Cad, Huzur Camii Sk, Akman Apt. No. 1/1, Daire 9 Uskudar, 81140 Istanbul, Turkey |
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| Abstract: | ![]()
Rosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the 4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone. Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and improved ALT, alkaline phosphatase, and interleukin-6 levels in the induction study and interleukin-1β, interleukin-6, and tumor necrosis factor-α levels in the treatment study. Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone’s effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH. |
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| Keywords: | Rosiglitazone Insulin resistance Nonalcoholic fatty liver disease Oral glucose tolerance test Reactive oxygen species Cytokine Interleukin Tumor necrosis factor |
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