原发性青光眼视网膜神经纤维层厚度和视盘周围血管密度分析

目的 探讨原发性闭角型青光眼(PACG)和原发性开角型青光眼(POAG)患者视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度、视盘周围血管密度(circumpapil-lary vascular density,cpVD)及视野平均敏感度(mean sensitivity,MS)之间...

Analysis of retinal nerve fiber layer thickness and circumpapillary vascular density in patients with primary glaucoma

Objective To investigate the relationship among retinal nerve fiber layer(RNFL)thickness,circumpapillary vascular density(cpVD)and mean sensitivity(MS)of visual field in patients with primary angle-closure glaucoma(PACG)and primary open-angle glaucoma(POAG),and explore the difference in the nature of the two diseases.Methods The clinical data of 120 POAG patients(120 eyes)and 120 PACG patients(120 eyes)with matched age and MS of visual field who were treated in our hospital from July 2016 to July 2018 were retrospectively analyzed.The mean RNFL thickness,mean cpVD,and[superotemporal(ST),superonasal(SN),nasoupper(NU),nasolower(NL),inferonasal(IN),inferotemoporal(IT),temporolower(TL),temporoupper(TU)]RNFL thickness and cpVD were detected by optical coherence tomography angiography(OCTA).The MS of total visual field and in different directions were detected by an automatic perimeter.The relationship among RNFL thickness,cpVD and MS of visual field in different directions,and related factors affecting cpVD were analyzed.Results There was a correlation among mean RNCL thickness,mean cpVD and mean MS of visual field in PACG group and POAG group(both P<0.05).RNFL thickness in ST,SN,IT and IN four directions were related to corresponding MS of visual field in PACG group(all P<0.05).The cpVD in ST,SN,IT,IN and TL five directions were related to corresponding MS of visual field(all P<0.05).The cpVD in all directions were related to corresponding RNFLT and MS of visual field in POAG group(all P<0.05).The intraocular pressure and RNFL thickness of PACG eyes were independent factors affecting cpVD(P<0.05).Only RNFL thickness of POAG eyes was an independent factor affecting cpVD(P<0.05).Conclusion Compared with POAG patients,cpVD had closer relationship with MS of visual field for PACG patients,indicating difference in terms of blood vessels and function between POAG and PACG,which may be related to their different pathogenesis.