康柏西普玻璃体内注射治疗特发性脉络膜新生血管

目的 探究康柏西普玻璃体内注射治疗特发性脉络膜新生血管(idiopathic cho-roidal neovascularization,ICNV)的疗效.方法 选择2016年1月至2018年1月我院眼科收治的ICNV患者146例(146眼)纳入研究,所有患者均行玻璃体内注射康柏西普治疗,测量治疗前后最佳矫正视力(BC...

Intravitreal injection of Conbercept in treatment of patients with idiopathic choroidal neovascularization

Objective To investigate the curative effect of intravitreal injection of Conbercept in the treatment of idiopathic choroidal neovascularization(ICNV).Methods Totally 146 ICNV patients(146 eyes)admitted to our Ophthalmology Department from January 2016 to January 2018 were enrolled in the study.All patients underwent intravitreal injection of Conbercept.The best corrected visual acuity(BCVA),intraocular pressure(IOP),subfoveal choroidal thickness(SFCT),superior choroidal thickness(SCT),inferior choroidal thickness(ICT),nasal choroidal thickness(NCT)and temporal choroidal thickness(TCT)before and after treatment were measured.Leakage condition of choroidal neovascularization(CNV)was observed and evaluated.BCVA,IOP and choroidal thickness in each region,and difference in choroidal thickness between affected eyes and contralateral eyes were compared before and after treatment.The choroidal thickness of the affected eye and contralateral eye were compared.Results Compared with that before treatment,BCVA of the affected eyes significantly improved at 1 day and 1 month after treatment(both P<0.05).There were no significant differences in IOP of the affected eyes before and after treatment(both P>0.05).The leakage area of the affected eyes decreased after 12 months of follow-up.The response rate of CNV leakage treatment was 80.82%.The SFCT,NCT 2.2 mm,TCT 2.2 mm and TCT 3.45 mm of the affected eyes were significantly higher than those of the contralateral eyes(all P<0.05).Compared with that before treatment,the choroidal thickness in all sites of affected eyes significantly decreased at 12 months after treatment(all P<0.05).There were no serious adverse reactions during or after treatment.Conclusion Intravitreal injection of Conbercept can improve the visual acuity of ICNV patients,reduce the symptoms of retinal leakage,and reduce SFCT that has a good effect.