无症状HBsAg携带者传染性与年龄关系的研究

本文应用斑点杂交试验直接检测154例无症状HBsAg携带者血清HBV DNA,四个年龄组HBV DNA阳性率分别为:11月～15岁82.3％(28/34),～30岁67.8％(40/59),～40岁37.1％(13/35),41～60岁19.2％(5/26),其间有显著差异(X~2=32.1675 P<0.01)。四个年龄组HBeAg阳性率分别为:82.3％(28/34),67.8％(40/59),40％(14/35),26.9％(7/26),其间有显著差异(X~2=25.5248 P<0.01)。各组HBVDNA检出与HBeAg存在密切相关,与HBsAg、抗-HBe及抗—HBe阳性或阴性并无相关。结果表明无症状HBsAg携带者随着年龄增长,血清HBV复制水平降低,传染性减小。所以,在防治无症状HBsAg携带者构成社会极重要的传染源的同时,要特别注意小儿及青少年无症状HBsAg搏带者的防治。

DIRECT SPOT HYBRIDIZATION ASSAY FOR DETECTION OF SERUM HBV DNA

Direct spot hybridization assay for detectio of serum HBV DNA in 154 asymptomatic HBsAg carriers was presented. In four age groups, the positive rates of HBV DNA were 82.3％ (28/34) for 11 months to 15years, 67.8％(40/59) for 16 to 30 years, 37.1％(13/35) for 31 to 40 years, and 19.2％ (5/26) for 41 to 60 years, respectively. There were significant differerences among these four groups (x~2 = 32.1675,p<0.01)The positive rates of HBeAg were 82.3％ (28/34), 67.8％(40/59), 40％ (14/35) and 26.9 (7/26), respectively in same groups, with significant statistical differences (x~2=25.5248, p<0.01). There were close correlations between HBV DNA and HB eAg and no correlation of positiven-ess or negativenss for HBsAg, anti HBc and anti. HBe in each gronp.These results indicate that with inc reasing of age of asymptomatic HBs-Ag carriers the levels of replication of serum BHV vere depleted, and infectivity reduced. Hence, in the tre atment and prophylaxis of asymptom atic carriers it showed ray much att ention to the young and adolescent patients.