| 类风湿关节炎患者外周血CD4+CD25+CD127-调节T细胞的检测及临床意义 |
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| 引用本文： | 王庆保,刘健,万磊.类风湿关节炎患者外周血CD4+CD25+CD127-调节T细胞的检测及临床意义[J].安徽医学,2010,31(2):131-134. |
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| 作者姓名： | 王庆保 刘健 万磊 |
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| 作者单位： | 安徽中医学院第一附属医院检验中心,合肥,230031;安徽中医学院第一附属医院检验中心,合肥,230031;安徽中医学院第一附属医院检验中心,合肥,230031 |
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| 摘 要： | 目的探讨CD4＋CD25＋CD127-调节T细胞（Treg）在类风湿关节炎中的诊断价值及临床意义。方法选取42例类风湿关节炎（RA）患者和20正常健康者分为两组,采用流式细胞仪检测两组调节T细胞的表达频率,检测两组实验室指标,观察两组实验室指标与调节T细胞的关系。结果与正常对照组相比,RA组白细胞（WBC）、免疫球蛋白A（IgA）、抗链球菌溶血素O（ASO）、类风湿因子（RF）、糖酸蛋白（α1-AGP）、C反应蛋白（CRP）、血沉（ESR）显著升高（P〈0.05或P〈0.01）;血红蛋白（Hb）、CD25＋T细胞、CD4＋CD25＋T细胞、CD4＋CD25＋CD127-T细胞的表达频率降低（P〈0.05）。Spearman相关分析显示,CD25＋T细胞与Hb、IgM、ESR呈正相关,CD4＋CD25＋CD127-T细胞与IgM呈正相关（P〈0.01或P〈0.05）;CD25＋T细胞与RBC、IgA呈负相关,CD4＋CD25＋T细胞与补体C4呈负相关,CD4＋CD25＋CD127-T细胞与ASO呈负相关（P〈0.05）。结论CD4＋CD25＋CD127-Treg在RA患者的外周血中显著降低,并且与疾病的活动性高度相关,说明调节T细胞可能参与了RA的发病,早期检测可能为RA的诊断及治疗提供依据。
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| 关 键 词： | 类风湿关节炎 CD4+CD25+CD127-调节T细胞 流式细胞术 免疫学机制 |
Detection of regulatory CD4+CD25+CD127-T cells in asthma patients and its clinical significance |
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| Wang Qinbao,Liu Jian,Wan Lei.Detection of regulatory CD4+CD25+CD127-T cells in asthma patients and its clinical significance[J].Anhui Medical Journal,2010,31(2):131-134. |
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| Authors: | Wang Qinbao Liu Jian Wan Lei |
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| Institution: | Wang Qinbao,Liu Jian,Wan Lei Clinical Laboratory Center the First Affliated Hospital of Anhui college of TCM,Hefei 230031,China |
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| Abstract: | Objective To evaluate the diagnosis and clinical significance of T cells(Treg) in rheumatoid arthritis.Methods Forty-two cases of rheumatoid arthritis(RA) patients and twenty normal healthy volunteers were chosen for this study.The proportion of CD4+CD25+CD127T cells population in total T cells was evaluated by flow cytometric analysis.Detect two groups of laboratory indexes,The relationship between T-cell and two sets of laboratory indicators was observed.Results Compared with normal control group,white bl... |
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| Keywords: | Rheumatoid arthritis CD4+CD25+CD127-regulating T-cell Flow cytometry Immunological mechanisms |
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