Evidence for a dose-dependent effect of pulsed magnetic fields on pain processing |
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| Authors: | John A. Robertson,Nicole Juen,Jean Thé berge,Julie Weller,Dick J. Drost,Frank S. Prato,Alex W. Thomas |
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| Affiliation: | 1. Imaging Program, Lawson Health Research Institute, London, ON, Canada;2. Diagnostic Imaging, St. Joseph''s Health Care, London, ON, Canada;3. Dept. of Medical Biophysics, University of Western Ontario, London, ON, Canada |
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| Abstract: | Functional magnetic resonance imaging (fMRI) was used to investigate the dose–response relationship (sham, 100, 200, 1000 μT) between a pulsed extremely low frequency magnetic field (ELFMF) and acute thermal pain on the dominant right hand. Forty-seven participants were recruited, and pulsed ELFMF was applied through the MRI gradient system using a novel technique. Regions of interest (ROIs) matching those of previous studies were examined for a potential dose response. Significant correlations between applied field strength and change in BOLD activity were found in the anterior cingulate and the ipsilateral insula, indicating that there might be either a dose response or a threshold effect of the ELFMF. |
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| Keywords: | fMRI Nociception Magnetic fields Induced currents Bioelectromagnetics |
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