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Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder |
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| Authors: | Ryota Hashimoto Hitoshi Hashimoto Norihito Shintani Kazutaka Ohi Hiroaki Hori Osamu Saitoh Asako Kosuga Masahiko Tatsumi Nakao Iwata Norio Ozaki Kunitoshi Kamijima Akemichi Baba Masatoshi Takeda Hiroshi Kunugi |
| Affiliation: | 1. The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;2. Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan;3. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan;4. Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan;5. Department of Psychiatry, National Center Hospital of Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan;6. Department of Psychiatry, Showa University School of Medicine, Shinagawaku, Tokyo 142-8666, Japan;g Yokohama Shinryo Clinic, Yamamotobiru 2F, 3-28-5 Tsuruyacho, Kanagawaku, Yokohama 221-0835, Japan;h Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan;i Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan |
| Abstract: | Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD. |
| Keywords: | PACAP ADCYAP1 Major depressive disorder Depression Single nucleotide polymorphism |
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