Isobolographic analysis of caramiphen and lidocaine on spinal anesthesia in rats |
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| Authors: | Yu-Wen Chen Chin-Chen Chu Yu-Chung Chen Jhi-Joung Wang Ching-Hsia Hung |
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| Affiliation: | 1. Department of Physical Therapy, China Medical University, Taichung, Taiwan;2. Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan;3. Division of Physical Therapy, Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan;4. Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan |
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| Abstract: | ![]()
The aims of the study were to evaluate the spinal anesthetic effect of caramiphen and also assess spinal anesthetic interactions of caramiphen with lidocaine. Lidocaine, a common local anesthetic, was used as control. Dose-dependent responses of intrathecal caramiphen on spinal anesthesia were compared with lidocaine in rats. The interactions of caramiphen with lidocaine were evaluated via an isobolographic analysis. Caramiphen and lidocaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED50) basis, the spinal anesthetic effect of caramiphen was more potent than lidocaine (P < 0.01 for each comparison). Co-administration of caramiphen with lidocaine produced an additive effect. Caramiphen and lidocaine are known to have local anesthetic effects as spinal anesthesia in rats. The spinal anesthetic effects of adding caramiphen to lidocaine are similar to the combinations of other anesthetics with lidocaine. |
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| Keywords: | Caramiphen Lidocaine Spinal anesthesia Isobolographic analysis |
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